Physical activity and risk of bleeding in elderly patients taking anticoagulants.

Détails

ID Serval
serval:BIB_BC0D39BD89BE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Physical activity and risk of bleeding in elderly patients taking anticoagulants.
Périodique
Journal of thrombosis and haemostasis : JTH
Auteur(s)
Frey P.M., Méan M., Limacher A., Jaeger K., Beer H.J., Frauchiger B., Aschwanden M., Rodondi N., Righini M., Egloff M., Osterwalder J., Kucher N., Angelillo-Scherrer A., Husmann M., Banyai M., Matter C.M., Aujesky D.
ISSN
1538-7836 (Electronic)
ISSN-L
1538-7836
Statut éditorial
Publié
Date de publication
02/2015
Volume
13
Numéro
2
Pages
197-205
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Although the possibility of bleeding during anticoagulant treatment may limit patients from taking part in physical activity, the association between physical activity and anticoagulation-related bleeding is uncertain.
To determine whether physical activity is associated with bleeding in elderly patients taking anticoagulants.
In a prospective multicenter cohort study of 988 patients aged ≥ 65 years receiving anticoagulants for venous thromboembolism, we assessed patients' self-reported physical activity level. The primary outcome was the time to a first major bleeding, defined as fatal bleeding, symptomatic bleeding in a critical site, or bleeding causing a fall in hemoglobin or leading to transfusions. The secondary outcome was the time to a first clinically relevant non-major bleeding. We examined the association between physical activity level and time to a first bleeding by using competing risk regression, accounting for death as a competing event. We adjusted for known bleeding risk factors and anticoagulation as a time-varying covariate.
During a mean follow-up of 22 months, patients with a low, moderate, and high physical activity level had an incidence of major bleeding of 11.6, 6.3, and 3.1 events per 100 patient-years and an incidence of clinically relevant non-major bleeding of 14.0, 10.3, and 7.7 events per 100 patient-years, respectively. A high physical activity level was significantly associated with a lower risk of major bleeding (adjusted sub-hazard ratio 0.40, 95% confidence interval 0.22-0.72). There was no association between physical activity and non-major bleeding.
A high level of physical activity is associated with a decreased risk of major bleeding in elderly patients receiving anticoagulant therapy.

Mots-clé
Age Factors, Aged, Aged, 80 and over, Anticoagulants/adverse effects, Female, Hemorrhage/blood, Hemorrhage/chemically induced, Hemorrhage/diagnosis, Hemorrhage/mortality, Hemorrhage/prevention & control, Humans, Incidence, Male, Motor Activity, Prospective Studies, Protective Factors, Risk Assessment, Risk Factors, Switzerland/epidemiology, Time Factors, Treatment Outcome, Venous Thromboembolism/blood, Venous Thromboembolism/diagnosis, Venous Thromboembolism/drug therapy
Pubmed
Création de la notice
06/01/2017 9:31
Dernière modification de la notice
21/08/2019 6:35
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