Neurons in the corpus callosum of the cat during postnatal development.

Détails

ID Serval
serval:BIB_BBC2BF6A4376
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Neurons in the corpus callosum of the cat during postnatal development.
Périodique
European Journal of Neuroscience
Auteur⸱e⸱s
Riederer B.M., Berbel P., Innocenti G.M.
ISSN
0953-816X (Print)
ISSN-L
0953-816X
Statut éditorial
Publié
Date de publication
2004
Volume
19
Numéro
8
Pages
2039-2046
Langue
anglais
Résumé
The corpus callosum (CC) is a major telencephalic commissure containing mainly cortico-cortical axons and glial cells. We have identified neurons in the CC of the cat and quantified their number at different postnatal ages. An antibody against microtubule-associated protein 2 was used as a marker of neurons. Immunocytochemical double-labelling with neuron-specific enolase or gamma-aminobutyric acid antibodies in the absence of glial fibrillary acidic protein positivity confirmed the neuronal phenotype of these cells. CC neurons were also stained with anti-calbindin and anti-calretinin antibodies, typical for interneurons, and with an anti-neurofilament antibody, which in neocortex detects pyramidal neurons. Together, these findings suggest that the CC contains a mixed population of neuronal types. The quantification was corrected for double counting of adjacent sections and volume changes during CC development. Our data show that CC neurons are numerous early postnatally, and their number decreases with age. At birth, about 570 neurons are found within the CC boundaries and their number drops to about 200 in the adult. The distribution of the neurons within the CC also changes in development. Initially, many neurons are found throughout the CC, while at later ages they become restricted to the boundaries of the CC, and in the adult to the rostrum of the CC close to the septum pellucidum or to the indusium griseum. Although origin and function of transient CC neurons in development and in adulthood remain unknown, they are likely to be interstitial neurons. Some of them have well-developed and differentiated processes and resemble pyramidal cells or interneurons. An axon-guiding function during the early postnatal period can not be excluded.
Mots-clé
Animals, Animals, Newborn, Cats, Corpus Callosum/chemistry, Corpus Callosum/cytology, Glial Fibrillary Acidic Protein/analysis, Microtubule-Associated Proteins/analysis, Neurons/chemistry, Neurons/cytology
Pubmed
Web of science
Création de la notice
24/01/2008 14:34
Dernière modification de la notice
20/08/2019 15:29
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