Decreasing body mass index is associated with cerebrospinal fluid markers of Alzheimer's pathology in MCI and mild dementia.

Détails

ID Serval
serval:BIB_BBBB0FB80665
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Decreasing body mass index is associated with cerebrospinal fluid markers of Alzheimer's pathology in MCI and mild dementia.
Périodique
Experimental gerontology
Auteur(s)
Mathys J., Gholamrezaee M., Henry H., von Gunten A., Popp J.
ISSN
1873-6815 (Electronic)
ISSN-L
0531-5565
Statut éditorial
Publié
Date de publication
15/12/2017
Peer-reviewed
Oui
Volume
100
Pages
45-53
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Several studies have identified an association between body mass index (BMI) and the incidence and severity of Alzheimer's disease (AD) but this relationship is not fully understood.
The primary objective of this study was to assess the possible association between BMI and cerebrospinal fluid (CSF) biomarkers of AD pathology in subjects with normal cognition and cognitive impairment. The secondary objective was to test whether BMI may contribute to improve the accuracy of a clinical model to predict AD pathology in memory clinic patients with cognitive impairment.
One hundred and seven elderly subjects with cognitive impairment (91 memory clinic patients with mild cognitive impairment [MCI] and 16 with dementia of AD type) and 55 cognitively healthy volunteers were included in this study. All subjects received a comprehensive clinical and neuropsychological evaluation and a lumbar puncture for CSF biomarker analysis. Multiple linear regressions and receiver operating characteristic (ROC) analyses were carried out to assess the association between BMI and the CSF biomarkers of AD pathology.
BMI was positively correlated with the CSF levels of Aβ <sub>42</sub> and negatively with tau and P-tau181 in participants with cognitive impairment. The associations were independent of age, sex, educational level, type and severity of cognitive impairment, cerebrovascular risk factors and the presence of the APOEε4 allele. Furthermore, BMI significantly improved the sensitivity and specificity of a multi-factorial model to predict the presence of an AD CSF biomarker profile.
Lower BMI is associated with cerebral AD pathology rather than with cognitive impairment in elderly subjects with MCI and mild dementia. Along with other clinical factors, decreasing BMI may help the clinician to identify patients with cognitive impairment due to AD.
Mots-clé
Aged, Aged, 80 and over, Alzheimer Disease/cerebrospinal fluid, Alzheimer Disease/diagnosis, Amyloid beta-Peptides/cerebrospinal fluid, Apolipoprotein E4/cerebrospinal fluid, Biomarkers/cerebrospinal fluid, Body Mass Index, Cognition, Cognitive Dysfunction/cerebrospinal fluid, Cognitive Dysfunction/diagnosis, Disease Progression, Female, Humans, Linear Models, Male, Middle Aged, Multivariate Analysis, Neuropsychological Tests, Peptide Fragments/cerebrospinal fluid, Prognosis, ROC Curve, tau Proteins/cerebrospinal fluid, Alzheimer's disease, Body mass index, Cerebrospinal fluid biomarkers, Dementia, Mild cognitive impairment, Weight loss
Pubmed
Web of science
Création de la notice
30/10/2017 10:44
Dernière modification de la notice
20/08/2019 15:29
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