A Systematic Phylogenetic Approach to Study the Interaction of HIV-1 With Coinfections, Noncommunicable Diseases, and Opportunistic Diseases.

Détails

ID Serval
serval:BIB_BB6E66056535
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A Systematic Phylogenetic Approach to Study the Interaction of HIV-1 With Coinfections, Noncommunicable Diseases, and Opportunistic Diseases.
Périodique
The Journal of infectious diseases
Auteur⸱e⸱s
Kusejko K., Bachmann N., Chaudron S.E., Nguyen H., Braun D.L., Hampel B., Battegay M., Bernasconi E., Calmy A., Cavassini M., Hoffmann M., Böni J., Yerly S., Klimkait T., Perreau M., Rauch A., Günthard H.F., Kouyos R.D.
Collaborateur⸱rice⸱s
Swiss HIV Cohort Study
ISSN
1537-6613 (Electronic)
ISSN-L
0022-1899
Statut éditorial
Publié
Date de publication
19/06/2019
Peer-reviewed
Oui
Volume
220
Numéro
2
Pages
244-253
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
To systematically test whether coinfections spread along the HIV-1 transmission network and whether similarities in HIV-1 genomes predict AIDS-defining illnesses and comorbidities, we analyzed the distribution of these variables on the HIV phylogeny of the densely sampled Swiss HIV Cohort Study. By combining different statistical methods, we could detect, quantify, and explain the clustering of diseases. Infectious conditions such as hepatitis C, but also Kaposi sarcoma, clustered significantly, suggesting transmission of these infections along the HIV-1 transmission network. The clustering of patients with neurocognitive complaints could not be completely explained by the clustering of patients with similar demographic risk factors, which suggests a potential impact of viral genetics. In summary, the consistent and robust signal for coinfections and comorbidities highlights the strong interaction of HIV-1 and other infections and shows the potential of combining phylogenetic methods to identify disease traits that are likely to be related to virus genetic factors.
Mots-clé
AIDS-Related Opportunistic Infections/virology, Coinfection/virology, Female, HIV Infections/virology, HIV-1/genetics, Hepacivirus/genetics, Hepatitis C/virology, Humans, Male, Middle Aged, Noncommunicable Diseases, Phylogeny, Prospective Studies, HIV, coinfections, comorbidities, opportunistic infections, phylogenetic analysis
Pubmed
Web of science
Création de la notice
07/04/2019 14:06
Dernière modification de la notice
28/02/2020 6:19
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