Decreased behavioral impairments in an Alzheimer mice model by interfering with TNF-alpha metabolism.

Détails

ID Serval
serval:BIB_BB66C769237B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Decreased behavioral impairments in an Alzheimer mice model by interfering with TNF-alpha metabolism.
Périodique
Brain Research Bulletin
Auteur(s)
Giuliani F., Vernay A., Leuba G., Schenk F.
ISSN
1873-2747[electronic]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
80
Numéro
4-5
Pages
302-308
Langue
anglais
Résumé
The performance of mice expressing PDAPP (+/+ or +/-) was studied in the Morris place navigation task. Different lines of questions were investigated using PDAPP+/- mice in which the activity of the cytokine Tumor Necrosing Factor alpha (TNFalpha) was attenuated by chronic treatment with anti-TNF or deleting TNFalpha (TNF-/-). Two different categories of behavior were analyzed in adult (6 months) and middle aged (15 months) subjects. Classically, the cognitive performance was assessed from the escape efficacy and quantitative bias toward the training position in a Morris water maze. Second, stereotyped circling was quantified, along with more qualitative behavioral impairments such as self-mutilation or increased reactivity. Our results can be summarized as follows. (1) All of the PDAPP mice expressed reduced cognitive performance in the Morris task, but only those with a clear-cut amyloid burden in the hippocampus showed behavioral abnormalities such as stereotyped circling. (2) Chronic treatment with anti-TNF prevented the development of pathological circling in the 6-month-old mice but not in the 15-month-old mice and had no significant effect on amyloid burden. (3) The absence of TNFalpha prevented the development of stereotyped circling in 6- and 15-month-old mice but increased amyloid burden after 15 months. These data indicate that PDAPP mice express cognitive impairments disregarding absence of TNF. The pathological behavioral anomalies related to the PDAPP mutation seem reduced by treatments interfering with TNFalpha.
Pubmed
Web of science
Création de la notice
14/10/2009 9:11
Dernière modification de la notice
20/08/2019 16:29
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