Adaptations of Natural Killer Cells to Self-MHC Class I.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_BB450D1901CE
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Adaptations of Natural Killer Cells to Self-MHC Class I.
Périodique
Frontiers in Immunology
Auteur(s)
Bessoles S., Grandclément C., Alari-Pahissa E., Gehrig J., Jeevan-Raj B., Held W.
ISSN
1664-3224 (Electronic)
ISSN-L
1664-3224
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
5
Pages
349
Langue
anglais
Notes
Publication types: Journal Article Publication Status: epublish, pdf:Focused Review ARTICLE
Résumé
Natural Killer (NK) cells use germ line encoded receptors to detect diseased host cells. Despite the invariant recognition structures, NK cells have a significant ability to adapt to their surroundings, such as the presence or absence of MHC class I molecules. It has been assumed that this adaptation occurs during NK cell development, but recent findings show that mature NK cells can also adapt to the presence or absence of MHC class I molecules. Here, we summarize how NK cells adjust to changes in the expression of MHC class I molecules. We propose an extension of existing models, in which MHC class I recognition during NK cell development sequentially instructs and maintains NK cell function. The elucidation of the molecular basis of the two effects may identify ways to improve the fitness of NK cells and to prevent the loss of NK cell function due to persistent alterations in their environment.
Pubmed
Web of science
Open Access
Oui
Création de la notice
31/05/2015 9:59
Dernière modification de la notice
20/08/2019 16:29
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