The T cell receptor V beta repertoire in HIV-1 infection and disease

Détails

ID Serval
serval:BIB_BB3F13EDA58D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The T cell receptor V beta repertoire in HIV-1 infection and disease
Périodique
Seminars in Immunology
Auteur⸱e⸱s
Soudeyns  H., Rebai  N., Pantaleo  G. P., Ciurli  C., Boghossian  T., Sekaly  R. P., Fauci  A. S.
ISSN
1044-5323 (Print)
Statut éditorial
Publié
Date de publication
06/1993
Volume
5
Numéro
3
Pages
175-85
Notes
Comparative Study
Journal Article
Review --- Old month value: Jun
Résumé
Viral superantigens (SAg) were shown in mice to induce anergy and deletion of T cells bearing specific T cell receptor V beta subsets, these perturbations being mainly restricted to CD4+ T cells. In accordance with this model, a putative HIV-associated SAg could contribute to the pathogenesis of HIV-1 infection and AIDS. To reveal the presence of this putative molecule, three study protocols were designed that relied on the fact that similarity of the expressed V beta repertoire of a given pair of individuals is proportional to the relative likeness of their MHC background: (1) by using a quantitative PCR technique that allows simultaneous typing of 24 V beta families, the V beta repertoires of HIV-discordant monozygotic twins were compared; (2) the V beta repertoire found in lymph nodes of HIV-infected subjects was contrasted to that found in peripheral blood of the same individuals; (3) the V beta repertoire of a cohort of HIV-infected mothers was compared with that of their HIV-infected and uninfected children. Results from these approaches revealed that significant perturbations of the TCR V beta repertoire were taking place in HIV-infected subjects, and that these alterations were restricted to T cells expressing specific V beta s. These results are consistent with the presence of an HIV-associated SAg in HIV-1 infection.
Mots-clé
Adult Animals Antigens, Bacterial/immunology Antigens, Viral/immunology Apoptosis CD4-Positive T-Lymphocytes/immunology/microbiology Cohort Studies Diseases in Twins Female Gene Rearrangement, beta-Chain T-Cell Antigen Receptor HIV Antigens/*immunology HIV Infections/congenital/*immunology *HIV-1/immunology HLA-D Antigens/immunology Humans Immune Tolerance Infant, Newborn Leukemia Virus, Murine/immunology/pathogenicity Lymph Nodes/immunology/pathology Lymphocyte Activation Mice Models, Biological Murine Acquired Immunodeficiency Syndrome/genetics/immunology/microbiology Pregnancy Pregnancy Complications, Infectious Receptors, Antigen, T-Cell, alpha-beta/*genetics Twins, Monozygotic
Pubmed
Création de la notice
25/01/2008 15:13
Dernière modification de la notice
20/08/2019 15:29
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