This paper examines the relationship of actor-network theory (ANT) and economic geography, arguing that there has been a rather restrictive, sometimes ambiguous reading of ANT literature. It reviews three major lines of reception in economic geography around the themes of topological space, translation and performativity. Subsequently, the paper problematizes conflicting interpretations of ‘network’ and ‘power’ as central ANT terms. In an attempt to open up new avenues of engagement with ANT, it finally sketches an agenda around three themes that are of relevance both for economic geography and for human geography more broadly: hybridity, desire and fluidity.