Measurement of glucose utilisation with [18F]2-fluoro-2-deoxy-D-glucose: a comparison of different analytical methods.

Détails

ID Serval
serval:BIB_BAE5979FA33F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Measurement of glucose utilisation with [18F]2-fluoro-2-deoxy-D-glucose: a comparison of different analytical methods.
Périodique
Journal of Cerebral Blood Flow and Metabolism
Auteur(s)
Lammertsma A.A., Brooks D.J., Frackowiak R.S., Beaney R.P., Herold S., Heather J.D., Palmer A.J., Jones T.
ISSN
0271-678X (Print)
ISSN-L
0271-678X
Statut éditorial
Publié
Date de publication
1987
Volume
7
Numéro
2
Pages
161-172
Langue
anglais
Notes
Publication types: Comparative Study ; Journal ArticlePublication Status: ppublish
Résumé
A number of different analytical methods were applied to dynamic scans obtained with [18F]2-fluoro-2-deoxy-D-glucose and positron emission tomography. In particular, methods applying three, four, standard, or no rate constants were compared in four studies on three normal subjects. In addition, regional cerebral blood flow, oxygen utilisation, and blood volume were measured using the oxygen-15 steady-state inhalation technique. There was a large difference between values of glucose utilisation obtained with the various analytical methods, in particular between methods using three or four rate constants. This difference was not due to contamination of the tracer with [18F]2-fluoro-2-deoxy-D-mannose. For dynamic techniques, the separate measurement of regional cerebral blood volume was essential. Static techniques (single scans with standard or no rate constants) were best related to dynamic techniques utilising four rate constants. From the results, it followed, however, that these static techniques can only be applied clinically if relatively large disturbances of glucose metabolism and no changes in rate constants are anticipated. The lumped constant was assessed from the combined measurement of oxygen and glucose utilisation and was higher than previously reported.
Mots-clé
Deoxy Sugars/diagnostic use, Deoxyglucose/analogs & derivatives, Deoxyglucose/diagnostic use, Fluorodeoxyglucose F18, Glucose/metabolism, Humans, Mathematics, Methods
Pubmed
Web of science
Open Access
Oui
Création de la notice
08/10/2011 14:55
Dernière modification de la notice
20/08/2019 15:28
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