Antioxidant power measurement in platelet concentrates treated by two pathogen inactivation systems in different blood centres.
Détails
ID Serval
serval:BIB_BADA5905137F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Antioxidant power measurement in platelet concentrates treated by two pathogen inactivation systems in different blood centres.
Périodique
Vox sanguinis
ISSN
1423-0410 (Electronic)
ISSN-L
0042-9007
Statut éditorial
Publié
Date de publication
01/2021
Peer-reviewed
Oui
Volume
116
Numéro
1
Pages
53-59
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Publication Status: ppublish
Résumé
The antioxidant power measurement can be useful to validate the execution of the pathogen inactivation treatment of platelet concentrates. The aim of this study is to evaluate the technology on different blood preparations including INTERCEPT and Mirasol treatments that are in routine use in Belgium and Luxemburg.
The antioxidant power measurement was tested on 78 apheresis platelet concentrates and 54 pools of buffy-coats-derived platelet concentrates before and after INTERCEPT treatment. In addition, 100 Reveos platelet pools were tested before and after Mirasol treatment. The antioxidant power was quantified electrochemically using disposable devices and was expressed as equivalent ascorbic acid concentration.
Mean results for apheresis platelet concentrates were of 90 ± 14 and 35 ± 10 µmol/l eq. ascorbic acid before and after INTERCEPT treatment, respectively. The mean results for pools of buffy-coats-derived platelet concentrates were of 81 ± 10 and 29 ± 4 eq. µmol/l ascorbic acid before and after INTERCEPT treatment, respectively. For buffy-coats-derived platelet concentrates treated by Mirasol technology, the mean results were of 98 ± 11 and 32 ± 10 µmol/l eq. ascorbic acid before and after illumination, respectively.
The antioxidant power significantly decreases with pathogen inactivation treatments for platelet concentrates treated by INTERCEPT or Mirasol technologies.
The antioxidant power measurement was tested on 78 apheresis platelet concentrates and 54 pools of buffy-coats-derived platelet concentrates before and after INTERCEPT treatment. In addition, 100 Reveos platelet pools were tested before and after Mirasol treatment. The antioxidant power was quantified electrochemically using disposable devices and was expressed as equivalent ascorbic acid concentration.
Mean results for apheresis platelet concentrates were of 90 ± 14 and 35 ± 10 µmol/l eq. ascorbic acid before and after INTERCEPT treatment, respectively. The mean results for pools of buffy-coats-derived platelet concentrates were of 81 ± 10 and 29 ± 4 eq. µmol/l ascorbic acid before and after INTERCEPT treatment, respectively. For buffy-coats-derived platelet concentrates treated by Mirasol technology, the mean results were of 98 ± 11 and 32 ± 10 µmol/l eq. ascorbic acid before and after illumination, respectively.
The antioxidant power significantly decreases with pathogen inactivation treatments for platelet concentrates treated by INTERCEPT or Mirasol technologies.
Mots-clé
Antioxidants/analysis, Blood Platelets/chemistry, Blood Platelets/radiation effects, Blood Preservation, Female, Furocoumarins, Humans, Male, Plateletpheresis, Ultraviolet Rays, antioxidant power, pathogen inactivation, platelet concentrates
Pubmed
Web of science
Création de la notice
25/08/2020 10:13
Dernière modification de la notice
20/03/2021 7:22
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