Differential effects of a monoclonal antibody to cis-urocanic acid on the suppression of delayed and contact hypersensitivity following ultraviolet irradiation
Détails
ID Serval
serval:BIB_BA9EEE750971
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Differential effects of a monoclonal antibody to cis-urocanic acid on the suppression of delayed and contact hypersensitivity following ultraviolet irradiation
Périodique
Journal of Immunology
ISSN
0022-1767 (Print)
Statut éditorial
Publié
Date de publication
10/1996
Volume
157
Numéro
7
Pages
2891-9
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Oct 1
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Oct 1
Résumé
Urocanic acid (UCA) occurs naturally in the stratum corneum of the skin as the trans-isomer and, upon exposure to UVB radiation, converts to cis-UCA. It has been proposed that trans-UCA is the photoreceptor for and, following its isomerization to cis-UCA, a mediator of the suppressive effects of UVB irradiation on systemic T cell-mediated immune responses, such as contact hypersensitivity (CH) and delayed-type hypersensitivity (DTH). To address this question directly, we studied the consequence of deleting the in vivo function of cis-UCA on systemic suppression of CH and DTH, by injecting mice with a anti-cis-UCA mAb several hours before exposure to UVB radiation. We found that while DTH responses were completely restored, the anti-cis-UCA Ab had no effect on UV-induced immunosuppression of the CH response, even though suppressor cell formation was inhibited in both cases. Further, the kinetics of IL-10 expression in the skin of irradiated mice injected with the anti-cis-UCA mAb was altered and the diminished APC function of spleen-adherent cells from UVB-irradiated mice was totally reversed by the Ab. These findings suggest that cis-UCA acts as a mediator for some but not all of the systemic suppressive effects of UVB irradiation. They also suggest that cis-UCA may act indirectly via IL-10 to modulate immune function.
Mots-clé
Adoptive Transfer
Animals
Antibodies, Monoclonal/*immunology
Antigen-Presenting Cells/*immunology
Dermatitis, Allergic Contact/*immunology
Erythrocytes/immunology
Hypersensitivity, Delayed/*immunology
*Immunosuppression
Interleukin-10/physiology
Isomerism
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Oxazolone/immunology
Sheep/blood
Signal Transduction/*radiation effects
Skin/*immunology/metabolism/radiation effects
Specific Pathogen-Free Organisms
Spleen/immunology
T-Lymphocyte Subsets/*immunology
T-Lymphocytes, Regulatory/*immunology
*Ultraviolet Rays
Urocanic Acid/*antagonists & inhibitors/chemistry/immunology/radiation
effects
Pubmed
Web of science
Création de la notice
25/01/2008 17:50
Dernière modification de la notice
20/08/2019 16:28