Increased exploratory activity and altered response to LSD in mice lacking the 5-HT(5A) receptor

Détails

ID Serval
serval:BIB_BA7BA7AB1438
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Increased exploratory activity and altered response to LSD in mice lacking the 5-HT(5A) receptor
Périodique
Neuron
Auteur(s)
Grailhe  R., Waeber  C., Dulawa  S. C., Hornung  J. P., Zhuang  X., Brunner  D., Geyer  M. A., Hen  R.
ISSN
0896-6273 (Print)
Statut éditorial
Publié
Date de publication
03/1999
Volume
22
Numéro
3
Pages
581-91
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Mar
Résumé
In order to determine the distribution and function of the 5-HT5A serotonin receptor subtype, we generated knockout mice lacking the 5-HT5A gene. Comparative autoradiography studies of brains of wild-type (wt) and 5-HT5A knockout (5A-KO) mice revealed the existence of binding sites with high affinity for [125I]LSD that correspond to 5-HT5A receptors and that are concentrated in the olfactory bulb, neocortex, and medial habenula. When exposed to novel environments, the 5A-KO mice displayed increased exploratory activity but no change in anxiety-related behaviors. In addition, the stimulatory effect of LSD on exploratory activity was attenuated in 5A-KO mice. These results suggest that 5-HT5A receptors modulate the activity of neural circuits involved specifically in exploratory behavior and suggest that some of the psychotropic effects of LSD may be mediated by 5-HT5A receptors.
Mots-clé
Animals Animals, Newborn Anxiety/physiopathology Autoradiography Exploratory Behavior/*physiology Hallucinogens/*pharmacology Immunohistochemistry Lysergic Acid Diethylamide/*pharmacology Male Mice Mice, Knockout Motor Activity/drug effects/physiology Receptors, Serotonin/genetics/*physiology Startle Reaction/drug effects/genetics/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 15:22
Dernière modification de la notice
20/08/2019 16:28
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