The role of the Fanconi anemia network in the response to DNA replication stress.
Détails
ID Serval
serval:BIB_BA71FDED0DD3
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The role of the Fanconi anemia network in the response to DNA replication stress.
Périodique
Critical reviews in biochemistry and molecular biology
ISSN
1549-7798[electronic]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
44
Numéro
5
Pages
292-325
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Fanconi anemia is a genetically heterogeneous disorder associated with chromosome instability and a highly elevated risk for developing cancer. The mutated genes encode proteins involved in the cellular response to DNA replication stress. Fanconi anemia proteins are extensively connected with DNA caretaker proteins, and appear to function as a hub for the coordination of DNA repair with DNA replication and cell cycle progression. At a molecular level, however, the raison d'être of Fanconi anemia proteins still remains largely elusive. The thirteen Fanconi anemia proteins identified to date have not been embraced into a single and defined biological process. To help put the Fanconi anemia puzzle into perspective, we begin this review with a summary of the strategies employed by prokaryotes and eukaryotes to tolerate obstacles to the progression of replication forks. We then summarize what we know about Fanconi anemia with an emphasis on biochemical aspects, and discuss how the Fanconi anemia network, a late acquisition in evolution, may function to permit the faithful and complete duplication of our very large vertebrate chromosomes.
Mots-clé
Animals, Chromosomes, DNA/genetics, DNA Replication, Fanconi Anemia/genetics, Fanconi Anemia/metabolism, Fanconi Anemia Complementation Group Proteins/genetics, Fanconi Anemia Complementation Group Proteins/metabolism, Humans, Stress, Physiological
Pubmed
Web of science
Création de la notice
16/11/2009 15:09
Dernière modification de la notice
20/08/2019 15:28