Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions.

Détails

ID Serval
serval:BIB_BA54D58C102B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions.
Périodique
Psychological Medicine
Auteur(s)
Bench C.J., Friston K.J., Brown R.G., Frackowiak R.S., Dolan R.J.
ISSN
0033-2917 (Print)
ISSN-L
0033-2917
Statut éditorial
Publié
Date de publication
1993
Volume
23
Numéro
3
Pages
579-590
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Résumé
We have previously reported focal abnormalities of regional cerebral blood flow (rCBF) in a group of 33 patients with major depression. This report, on an extended sample of 40 patients who demonstrated identical regional deficits to those previously described, examines the relationships between depressive symptoms and patterns of rCBF. Patients' symptom ratings were subjected to factor analysis, producing a three-factor solution. The scores for these three factors, which corresponded to recognizable dimensions of depressive illness, were then correlated with rCBF. The first factor had high loadings for anxiety and correlated positively with rCBF in the posterior cingulate cortex and inferior parietal lobule bilaterally. The second factor had high loadings for psychomotor retardation and depressed mood and correlated negatively with rCBF in the left dorsolateral prefrontal cortex and left angular gyrus. The third factor had a high loading for cognitive performance and correlated positively with rCBF in the left medial prefrontal cortex. These data indicate that symptomatic specificity may be ascribed to regional functional deficits in major depressive illness.
Mots-clé
Adult, Antipsychotic Agents/therapeutic use, Brain/blood supply, Brain/physiopathology, Brain Diseases/diagnosis, Brain Diseases/physiopathology, Cerebrovascular Circulation, Depressive Disorder/complications, Depressive Disorder/diagnosis, Female, Functional Laterality/physiology, Glucose/metabolism, Humans, Neurotransmitter Agents/physiology, Parietal Lobe/blood supply, Parietal Lobe/physiopathology, Psychological Tests, Psychomotor Disorders/diagnosis, Psychomotor Disorders/etiology, Tomography, Emission-Computed/methods
Pubmed
Web of science
Création de la notice
22/09/2011 19:20
Dernière modification de la notice
20/08/2019 15:28
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