Microenvironmental regulation of tumour angiogenesis.

Détails

ID Serval
serval:BIB_BA44FA8CECE2
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Microenvironmental regulation of tumour angiogenesis.
Périodique
Nature reviews. Cancer
Auteur⸱e⸱s
De Palma M., Biziato D., Petrova T.V.
ISSN
1474-1768 (Electronic)
ISSN-L
1474-175X
Statut éditorial
Publié
Date de publication
08/2017
Peer-reviewed
Oui
Volume
17
Numéro
8
Pages
457-474
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Tumours display considerable variation in the patterning and properties of angiogenic blood vessels, as well as in their responses to anti-angiogenic therapy. Angiogenic programming of neoplastic tissue is a multidimensional process regulated by cancer cells in concert with a variety of tumour-associated stromal cells and their bioactive products, which encompass cytokines and growth factors, the extracellular matrix and secreted microvesicles. In this Review, we discuss the extrinsic regulation of angiogenesis by the tumour microenvironment, highlighting potential vulnerabilities that could be targeted to improve the applicability and reach of anti-angiogenic cancer therapies.

Mots-clé
Adipocytes/physiology, Animals, Blood Platelets/physiology, Cancer-Associated Fibroblasts/physiology, Eosinophils/physiology, Extracellular Matrix/physiology, Extracellular Vesicles, Humans, Lymphocytes/physiology, Macrophages/physiology, Mast Cells/physiology, Myeloid Cells/physiology, Neoplasms/blood supply, Neoplasms/drug therapy, Neoplasms/metabolism, Neovascularization, Pathologic/physiopathology, Neutrophils/physiology, Pericytes/physiology, Tumor Microenvironment/physiology
Pubmed
Web of science
Création de la notice
11/09/2017 16:43
Dernière modification de la notice
20/08/2019 15:28
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