Impact of smoking on fertility and age of menopause: a population-based assessment.

Détails

Ressource 1Télécharger: Article-full-OK.pdf (1246.94 [Ko])
Etat: Public
Version: Après imprimatur
ID Serval
serval:BIB_BA186A5D8C76
Type
Thèse: thèse de doctorat.
Collection
Publications
Institution
Titre
Impact of smoking on fertility and age of menopause: a population-based assessment.
Auteur(s)
Oboni Jean-Baptiste
Directeur(s)
Waeber Gérard
Codirecteur(s)
Marques-Vidal Pedro Manuel, Vollenweider Peter
Détails de l'institution
Université de Lausanne, Faculté de biologie et médecine
Adresse
Faculté de biologie et de médecine
Université de Lausanne
CH-1015 Lausanne
SUISSE

Statut éditorial
Acceptée
Date de publication
2017
Langue
anglais
Résumé
Background and aims: Studies in patients seeking medically assisted reproduction have shown that smoking reduces fertility, but little information is available in the general population. We assessed the associations between smoking and the number of children, childbearing planning and age at menopause in a representative sample of the population of Lausanne, Switzerland.
Methods: Data from 6711 participants (3530 women, age range 35–75 years) collected between 2003 and 2006 and again in 2009 and 2012. Smoking status, number of offsprings and age of menopause were assessed.
Results: Women who currently smoke had significantly less children than former or never smokers: the number of children per women (average ±SD) was 1.38±1.05, 1.45±1.07 and 1.576±1.16, respectively ( p<0.001). Women who currently smoke had their first child at an earlier age than the others: 26.7±5.2, 27.4±5.4 and 26.9±5.2 years old for current, former and never smokers, respectively, ( p=0.01). Similar findings were found for men: number of children per men 1.475±1.16, 1.67±1.13 and 1.55 ±1.22 for current, former and never smokers, respectively ( p<0.001); no difference was found regarding age at the first child. The difference persisted after multivariate adjustment (adjusted for age, body mass index, Caucasian origins, alcohol consumption, caffeinated drinks consumption, educational level, receiving social help and women taking contraceptives) for the age at first child among women. No association was found between Heaviness of Smoking Index and the number of children among current smokers in both genders. Women who smoke had their menopause more than 1 year prior than never-smoking women (48.9±0.2 years compared with 47.8±0.3 years, respectively, p=0.002).
Conclusions: Smoking is associated with an earlier age of having the first child and of menopause among women.
Création de la notice
31/08/2017 9:58
Dernière modification de la notice
20/08/2019 15:28
Données d'usage