External validation of three lymph node ratio-based nomograms predicting survival using an international cohort of patients with resected pancreatic head ductal adenocarcinoma.

Détails

Ressource 1Télécharger: 1-s2.0-S0748798322004279-main.pdf (872.82 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_B9E513516124
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
External validation of three lymph node ratio-based nomograms predicting survival using an international cohort of patients with resected pancreatic head ductal adenocarcinoma.
Périodique
European journal of surgical oncology
Auteur⸱e⸱s
Schneider M., Labgaa I., Vrochides D., Zerbi A., Nappo G., Perinel J., Adham M., van Roessel S., Besselink M., Mieog JSD, Groen J.V., Demartines N., Schäfer M., Joliat G.R.
ISSN
1532-2157 (Electronic)
ISSN-L
0748-7983
Statut éditorial
Publié
Date de publication
09/2022
Peer-reviewed
Oui
Volume
48
Numéro
9
Pages
2002-2007
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Lymph node ratio (LNR) is an important prognostic factor of survival in patients with pancreatic ductal adenocarcinoma (PDAC). This study aimed to validate three LNR-based nomograms using an international cohort.
Consecutive PDAC patients who underwent upfront pancreatoduodenectomy from six centers (Europe/USA) were collected (2000-2017). Patients with metastases, R2 resection, missing LNR data, and who died within 90 postoperative days were excluded. The updated Amsterdam nomogram, the nomogram by Pu et al., and the nomogram by Li et al. were selected. For the validation, calibration, discrimination capacity, and clinical utility were assessed.
After exclusion of 176 patients, 1'113 patients were included. Median overall survival (OS) of the cohort was 23 months (95% CI: 21-25). For the three nomograms, Kaplan-Meier curves showed significant OS diminution with increasing scores (p < 0.01). All nomograms showed good calibration (non-significant Hosmer-Lemeshow tests). For the Amsterdam nomogram, area under the ROC curve (AUROC) for 3-year OS was 0.64 and 0.67 for 5-year OS. Sensitivity and specificity for 3-year OS prediction were 65% and 59%. Regarding the nomogram by Pu et al., AUROC for 3- and 5-year OS were 0.66 and 0.70. Sensitivity and specificity for 3-year OS prediction were 68% and 53%. For the Li nomogram, AUROC for 3- and 5-year OS were 0.67 and 0.71, while sensitivity and specificity for 3-year OS prediction were 63% and 60%.
The three nomograms were validated using an international cohort. Those nomograms can be used in clinical practice to evaluate survival after pancreatoduodenectomy for PDAC.
Mots-clé
Carcinoma, Pancreatic Ductal/pathology, Humans, Lymph Node Ratio, Neoplasm Staging, Nomograms, Pancreatic Neoplasms/pathology, Prognosis, Mortality, Pancreas cancer, Pancreatoduodenectomy, Prediction
Pubmed
Web of science
Open Access
Oui
Création de la notice
31/05/2022 10:00
Dernière modification de la notice
26/04/2023 6:14
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