A prospective observational study comparing a non-operator dependent automatic PWV analyser to pulse pressure, in assessing arterial stiffness in hemodialysis.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_B9CAA9B324E5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A prospective observational study comparing a non-operator dependent automatic PWV analyser to pulse pressure, in assessing arterial stiffness in hemodialysis.
Périodique
Bmc Nephrology
Auteur⸱e⸱s
Salvadé I., Schätti-Stählin S., Violetti E., Schönholzer C., Cereghetti C., Zwahlen H., Berwert L., Burnier M., Gabutti L.
ISSN
1471-2369 (Electronic)
ISSN-L
1471-2369
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
16
Numéro
1
Pages
62
Langue
anglais
Notes
Publication types: Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
BACKGROUND: Chronic kidney disease (CKD) accelerates vascular stiffening related to age. Arterial stiffness may be evaluated measuring the carotid-femoral pulse wave velocity (PWV) or more simply, as recommended by KDOQI, monitoring pulse pressure (PP). Both correlate to survival and incidence of cardiovascular disease. PWV can also be estimated on the brachial artery using a Mobil-O-Graph; a non-operator dependent automatic device. The aim was to analyse whether, in a dialysis population, PWV obtained by Mobil-O-Graph (MogPWV) is more sensitive for vascular aging than PP.
METHODS: A cohort of 143 patients from 4 dialysis units has been followed measuring MogPWV and PP every 3 to 6 months and compared to a control group with the same risk factors but an eGFR > 30 ml/min.
RESULTS: MogPWV contrarily to PP did discriminate the dialysis population from the control group. The mean difference translated in age between the two populations was 8.4 years. The increase in MogPWV, as a function of age, was more rapid in the dialysis group. 13.3% of the dialysis patients but only 3.0% of the control group were outliers for MogPWV. The mortality rate (16 out of 143) was similar in outliers and inliers (7.4 and 8.0%/year). Stratifying patients according to MogPWV, a significant difference in survival was seen. A high parathormone (PTH) and to be dialysed for a hypertensive nephropathy were associated to a higher baseline MogPWV.
CONCLUSIONS: Assessing PWV on the brachial artery using a Mobil-O-Graph is a valid and simple alternative, which, in the dialysis population, is more sensitive for vascular aging than PP. As demonstrated in previous studies PWV correlates to mortality. Among specific CKD risk factors only PTH is associated with a higher baseline PWV.
TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02327962.
Mots-clé
Aged, Aged, 80 and over, Automation, Blood Pressure/physiology, Brachial Artery/physiopathology, Brachial Artery/ultrasonography, Cohort Studies, Female, Humans, Kidney Failure, Chronic/physiopathology, Kidney Failure, Chronic/therapy, Male, Middle Aged, Prospective Studies, Pulse Wave Analysis/instrumentation, Pulse Wave Analysis/methods, Renal Dialysis, Sensitivity and Specificity, Sphygmomanometers, Vascular Stiffness/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/05/2015 15:52
Dernière modification de la notice
20/08/2019 15:27
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