Deficiency in short-chain fatty acid beta-oxidation affects theta oscillations during sleep.

Détails

ID Serval
serval:BIB_B9C7F31BB92B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Deficiency in short-chain fatty acid beta-oxidation affects theta oscillations during sleep.
Périodique
Nature Genetics
Auteur(s)
Tafti M., Petit B., Chollet D., Neidhart E., de Bilbao F., Kiss J.Z., Wood P.A., Franken P.
ISSN
1061-4036[print], 1061-4036[linking]
Statut éditorial
Publié
Date de publication
2003
Peer-reviewed
Oui
Volume
34
Numéro
3
Pages
320-325
Langue
anglais
Résumé
In rodents, the electroencephalogram (EEG) during paradoxical sleep and exploratory behavior is characterized by theta oscillations. Here we show that a deficiency in short-chain acyl-coenzyme A dehydrogenase (encoded by Acads) in mice causes a marked slowing in theta frequency during paradoxical sleep only. We found Acads expression in brain regions involved in theta generation, notably the hippocampus. Microarray analysis of gene expression in mice with mutations in Acads indicates overexpression of Glo1 (encoding glyoxylase 1), a gene involved in the detoxification of metabolic by-products. Administration of acetyl-L-carnitine (ALCAR) to mutant mice significantly recovers slow theta and Glo1 overexpression. Thus, an underappreciated metabolic pathway involving fatty acid beta-oxidation also regulates theta oscillations during sleep.
Mots-clé
Acetylcarnitine/administration & dosage, Acyl-CoA Dehydrogenase, Animals, Brain/enzymology, Disease Models, Animal, Electroencephalography, Fatty Acid Desaturases/deficiency, Fatty Acid Desaturases/genetics, Fatty Acids/metabolism, Immunoblotting, Immunoenzyme Techniques, In Situ Hybridization, Lactoylglutathione Lyase/metabolism, Liver/enzymology, Male, Mice, Mice, Inbred AKR, Mice, Inbred BALB C, Mice, Inbred C57BL, Molecular Sequence Data, Nootropic Agents/administration & dosage, Oligonucleotide Array Sequence Analysis, Oxidation-Reduction, Sleep, REM/drug effects, Theta Rhythm
Pubmed
Web of science
Création de la notice
24/01/2008 15:55
Dernière modification de la notice
20/08/2019 15:27
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