Age-independent association between arterial and bone remodeling in mild-to-moderate chronic kidney disease

Détails

ID Serval
serval:BIB_B9B66725D327
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Age-independent association between arterial and bone remodeling in mild-to-moderate chronic kidney disease
Périodique
Nephrol Dial Transplant
Auteur(s)
Briet M., Maruani G., Collin C., Bozec E., Gauci C., Boutouyrie P., Houillier P., Laurent S., Froissart M.
ISSN-L
1460-2385 (Electronic) 0931-0509 (Linking)
Statut éditorial
Publié
Date de publication
2010
Volume
25
Numéro
1
Pages
191-7
Notes
Briet, Marie
Maruani, Gerard
Collin, Cedric
Bozec, Erwan
Gauci, Cedric
Boutouyrie, Pierre
Houillier, Pascal
Laurent, Stephane
Froissart, Marc
eng
Research Support, Non-U.S. Gov't
England
2009/08/06 09:00
Nephrol Dial Transplant. 2010 Jan;25(1):191-7. doi: 10.1093/ndt/gfp373. Epub 2009 Aug 4.
Résumé
BACKGROUND: Damages to large arteries are related to bone disease in end-stage renal disease and contribute to cardiovascular mortality. An outward remodeling and stiffening of carotid artery already exist at an earlier stage of chronic kidney disease (CKD). We made the hypothesis that bone disease could be associated with the carotid outward remodeling in parallel with the decline of renal function in this population. METHODS: One hundred and seven patients (60.4 +/- 14.6 years) with CKD (mean glomerular filtration rate = 34 +/- 17 mL/min/1.73 m(2)) were included in this cross-sectional study. Common carotid artery diameter, intima-media thickness and carotid stiffness were determined with an echotracking system. Bone evaluation was performed by bone densitometry and the measurement of a bone-remodeling marker, bone-specific alkaline phosphatase (BSALP). RESULTS: After adjustment for age, sex, mean blood pressure, carotid pulse pressure and glomerular filtration rate, bone mineral densities measured at the radius, hip and lumbar spine were significantly and negatively correlated with carotid internal diameter (P = 0.0001, P = 0.0003, P = 0.01, respectively). This association exists only in patients with glomerular filtration rate < or =38 mL/min/ 1.73 m(2). BSALP was independently and positively correlated with carotid internal diameter and explained 13% of the variance. CONCLUSIONS: Bone mineral density and serum marker of bone remodeling are independently correlated with arterial remodeling in CKD patients suggesting a crosstalk between kidney, arterial wall and bone.
Mots-clé
Aged, Aging/*physiology, Bone Density/physiology, Bone Remodeling/*physiology, Carotid Arteries/*physiopathology, Chronic Disease, Cross-Sectional Studies, Elasticity/*physiology, Female, Glomerular Filtration Rate/physiology, Hip Joint/physiopathology, Humans, Kidney Diseases/*physiopathology, Lumbar Vertebrae/physiopathology, Male, Middle Aged, Regression Analysis, *Severity of Illness Index
Open Access
Oui
Création de la notice
03/03/2016 16:48
Dernière modification de la notice
21/08/2019 5:35
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