Desorption electrospray ionization mass spectrometry: direct toxicological screening and analysis of illicit Ecstasy tablets.

Détails

ID Serval
serval:BIB_B9A9585A13A0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Desorption electrospray ionization mass spectrometry: direct toxicological screening and analysis of illicit Ecstasy tablets.
Périodique
Rapid Communications in Mass Spectrometry
Auteur⸱e⸱s
Leuthold L.A., Mandscheff J.F., Fathi M., Giroud C., Augsburger M., Varesio E., Hopfgartner G.
ISSN
0951-4198
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
20
Numéro
2
Pages
103-110
Langue
anglais
Résumé
Desorption electrospray ionization mass spectrometry (DESI-MS) was used as a simple and rapid way to analyze drug tablets and powders without sample preparation. Experiments were performed with a home-made DESI source coupled to a triple-quadrupole linear-ion trap (QqQ(LIT)) mass spectrometer. Twenty-one commercial drugs as well as some illicit Ecstasy tablets and powders were analyzed. MS spectra almost exclusively showed the protonated or deprotonated ion of the drug after directing the pneumatically assisted electrospray onto the tablet's surface. With some tablets, inhomogeneity of the surface resulted in different spectra depending on the spot analyzed, thus showing that DESI could be used for imaging. Directly triggered MS/MS spectra were used for confirmatory analysis, with analysis times often below 10 s per tablet. For illicit Ecstasy tablets, DESI-MS, GC/MS and LC/MS analyses provided similar qualitative results for the main analytes. With MS/MS spectra library comparison or exact mass measurements, this technique could become very powerful for the rapid analysis of unknown tablets and shows the great potential of desorption techniques as an alternative to solution-based analysis.
Mots-clé
Drug Evaluation, Preclinical, Powders, Reproducibility of Results, Sensitivity and Specificity, Specimen Handling, Spectrometry, Mass, Electrospray Ionization, Street Drugs, Substance Abuse Detection, Tablets, Toxicity Tests
Pubmed
Web of science
Création de la notice
08/02/2008 17:43
Dernière modification de la notice
20/08/2019 15:27
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