SARS-CoV-2 structural features may explain limited neutralizing-antibody responses.

Détails

Ressource 1Télécharger: Sars41541-020-00264-6.pdf (1112.87 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_B9969183CF9D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Lettre (letter): communication adressée à l'éditeur.
Collection
Publications
Institution
Titre
SARS-CoV-2 structural features may explain limited neutralizing-antibody responses.
Périodique
NPJ vaccines
Auteur(s)
Bachmann M.F., Mohsen M.O., Zha L., Vogel M., Speiser D.E.
ISSN
2059-0105 (Electronic)
ISSN-L
2059-0105
Statut éditorial
Publié
Date de publication
04/01/2021
Peer-reviewed
Oui
Volume
6
Numéro
1
Pages
2
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Neutralizing antibody responses of SARS-CoV-2-infected patients may be low and of short duration. We propose here that coronaviruses employ a structural strategy to avoid strong and enduring antibody responses. Other viruses induce optimal and long-lived neutralizing antibody responses, thanks to 20 or more repetitive, rigid antigenic epitopes, spaced by 5–10 nm, present on the viral surface. Such arrays of repetitive and highly organized structures are recognized by the immune system as pathogen-associated structural patterns (PASPs), which are characteristic for pathogen surfaces. In contrast, coronaviruses are large particles with long spikes (S protein) embedded in a fluid membrane. Therefore, the neutralizing epitopes (which are on the S protein) are loosely “floating” and widely spaced by an average of about 25 nm. Consequently, recruitment of complement is poor and stimulation of B cells remains suboptimal, offering an explanation for the inefficient and short-lived neutralizing antibody responses.
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/01/2021 13:54
Dernière modification de la notice
15/03/2021 7:10
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