Pitfalls of measuring total blood calcium in patients with CKD

Détails

ID Serval
serval:BIB_B9874D63D02A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Pitfalls of measuring total blood calcium in patients with CKD
Périodique
J Am Soc Nephrol
Auteur(s)
Gauci C., Moranne O., Fouqueray B., de la Faille  R., Maruani G., Haymann  J. P., Jacquot C., Boffa  J. J., Flamant M., Rossert J., Urena P., Stengel B., Souberbielle  J. C., Froissart M., Houillier P.
Collaborateur(s)
NephroTest Study Group
ISSN-L
1533-3450 (Electronic) 1046-6673 (Linking)
Statut éditorial
Publié
Date de publication
2008
Volume
19
Numéro
8
Pages
1592-8
Notes
Gauci, Cedric
Moranne, Olivier
Fouqueray, Bruno
de la Faille, Renaud
Maruani, Gerard
Haymann, Jean-Philippe
Jacquot, Christian
Boffa, Jean-Jacques
Flamant, Martin
Rossert, Jerome
Urena, Pablo
Stengel, Benedicte
Souberbielle, Jean-Claude
Froissart, Marc
Houillier, Pascal
eng
Evaluation Studies
Research Support, Non-U.S. Gov't
2008/04/11 09:00
J Am Soc Nephrol. 2008 Aug;19(8):1592-8. doi: 10.1681/ASN.2007040449. Epub 2008 Apr 9.
Résumé
Disorders of mineral and bone metabolism are prevalent in patients with chronic kidney disease (CKD). The recent National Kidney Foundation Kidney Disease Outcomes Quality Initiative (K/DOQI) guidelines recommend that blood calcium (Ca) be regularly measured in patients with stages 3 to 5 CKD. The Kidney Disease: Improving Global Outcomes (KDIGO) position states that the measurement of ionized Ca (iCa) is preferred and that if total Ca (tCa) concentration is used instead, then it should be adjusted in the setting of hypoalbuminemia. In 691 consecutive patients with stages 3 to 5 CKD, we compared the ability of noncorrected and albumin-corrected tCa concentration to identify low, normal, or high iCa concentration. The agreement between noncorrected or albumin-corrected tCa and iCa was only fair. The risk for underestimating ionized calcium was independently increased by a low total CO(2) concentration when either noncorrected or albumin-corrected Ca was used and by a low albumin concentration only when noncorrected tCa was used. The risk for overestimating iCa was increased by a low albumin concentration only when albumin-corrected Ca was used. In conclusion, albumin-corrected tCa does not predict iCa better than noncorrected tCa. Moreover, both noncorrected and albumin-corrected tCa concentrations poorly predict hypo- or hypercalcemia in patients with CKD.
Mots-clé
Adolescent, Adult, Aged, Aged, 80 and over, Calcium/*blood, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Renal Insufficiency, Chronic/*blood, Serum Albumin/*metabolism
Open Access
Oui
Création de la notice
03/03/2016 16:49
Dernière modification de la notice
21/08/2019 5:35
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