A Monte Carlo-based procedure for independent monitor unit calculation in IMRT treatment plans.

Détails

ID Serval
serval:BIB_B973549F0199
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A Monte Carlo-based procedure for independent monitor unit calculation in IMRT treatment plans.
Périodique
Physics in Medicine and Biology
Auteur(s)
Pisaturo O., Moeckli R., Mirimanoff R.O., Bochud F.O.
ISSN
0031-9155
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
54
Numéro
13
Pages
4299-4310
Langue
anglais
Résumé
Intensity-modulated radiotherapy (IMRT) treatment plan verification by comparison with measured data requires having access to the linear accelerator and is time consuming. In this paper, we propose a method for monitor unit (MU) calculation and plan comparison for step and shoot IMRT based on the Monte Carlo code EGSnrc/BEAMnrc. The beamlets of an IMRT treatment plan are individually simulated using Monte Carlo and converted into absorbed dose to water per MU. The dose of the whole treatment can be expressed through a linear matrix equation of the MU and dose per MU of every beamlet. Due to the positivity of the absorbed dose and MU values, this equation is solved for the MU values using a non-negative least-squares fit optimization algorithm (NNLS). The Monte Carlo plan is formed by multiplying the Monte Carlo absorbed dose to water per MU with the Monte Carlo/NNLS MU. Several treatment plan localizations calculated with a commercial treatment planning system (TPS) are compared with the proposed method for validation. The Monte Carlo/NNLS MUs are close to the ones calculated by the TPS and lead to a treatment dose distribution which is clinically equivalent to the one calculated by the TPS. This procedure can be used as an IMRT QA and further development could allow this technique to be used for other radiotherapy techniques like tomotherapy or volumetric modulated arc therapy.
Mots-clé
Algorithms, Computer Simulation, Humans, Models, Biological, Monte Carlo Method, Radiometry/methods, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted/methods, Radiotherapy, Conformal/methods, Reproducibility of Results, Sensitivity and Specificity
Pubmed
Web of science
Création de la notice
29/09/2009 9:22
Dernière modification de la notice
20/08/2019 15:27
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