Spared nerve injury: an animal model of persistent peripheral neuropathic pain

Détails

ID Serval
serval:BIB_B94C3FEA363A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Spared nerve injury: an animal model of persistent peripheral neuropathic pain
Périodique
Pain
Auteur(s)
Decosterd  I., Woolf  C. J.
ISSN
0304-3959 (Print)
Statut éditorial
Publié
Date de publication
08/2000
Volume
87
Numéro
2
Pages
149-58
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Aug
Résumé
Peripheral neuropathic pain is produced by multiple etiological factors that initiate a number of diverse mechanisms operating at different sites and at different times and expressed both within, and across different disease states. Unraveling the mechanisms involved requires laboratory animal models that replicate as far as possible, the different pathophysiological changes present in patients. It is unlikely that a single animal model will include the full range of neuropathic pain mechanisms. A feature of several animal models of peripheral neuropathic pain is partial denervation. In the most frequently used models a mixture of intact and injured fibers is created by loose ligation of either the whole (Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988;33:87-107) or a tight ligation of a part (Seltzer Z, Dubner R, Shir Y. A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain 1990;43:205-218) of a large peripheral nerve, or a tight ligation of an entire spinal segmental nerve (Kim SH, Chung JM. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 1992;50:355-363). We have developed a variant of partial denervation, the spared nerve injury model. This involves a lesion of two of the three terminal branches of the sciatic nerve (tibial and common peroneal nerves) leaving the remaining sural nerve intact. The spared nerve injury model differs from the Chung spinal segmental nerve, the Bennett chronic constriction injury and the Seltzer partial sciatic nerve injury models in that the co-mingling of distal intact axons with degenerating axons is restricted, and it permits behavioral testing of the non-injured skin territories adjacent to the denervated areas. The spared nerve injury model results in early (<24 h), prolonged (>6 months), robust (all animals are responders) behavioral modifications. The mechanical (von Frey and pinprick) sensitivity and thermal (hot and cold) responsiveness is increased in the ipsilateral sural and to a lesser extent saphenous territories, without any change in heat thermal thresholds. Crush injury of the tibial and common peroneal nerves produce similar early changes, which return, however to baseline at 7-9 weeks. The spared nerve injury model may provide, therefore, an additional resource for unraveling the mechanisms responsible for the production of neuropathic pain.
Mots-clé
Animals *Disease Models, Animal Heat Hyperalgesia/*physiopathology/psychology Male Pain Threshold/*physiology/psychology Peripheral Nervous System Diseases/*physiopathology/psychology Rats Rats, Sprague-Dawley Sciatic Nerve/*injuries Sural Nerve/physiology
Pubmed
Web of science
Création de la notice
28/01/2008 11:45
Dernière modification de la notice
20/08/2019 16:27
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