Human commensal gut Proteobacteria withstand type VI secretion attacks through immunity protein-independent mechanisms.
Détails
Télécharger: 34599171_BIB_B94AF4021E42.pdf (1757.71 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_B94AF4021E42
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Human commensal gut Proteobacteria withstand type VI secretion attacks through immunity protein-independent mechanisms.
Périodique
Nature communications
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Statut éditorial
Publié
Date de publication
01/10/2021
Peer-reviewed
Oui
Volume
12
Numéro
1
Pages
5751
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Résumé
While the major virulence factors for Vibrio cholerae, the cause of the devastating diarrheal disease cholera, have been extensively studied, the initial intestinal colonization of the bacterium is not well understood because non-human adult animals are refractory to its colonization. Recent studies suggest the involvement of an interbacterial killing device known as the type VI secretion system (T6SS). Here, we tested the T6SS-dependent interaction of V. cholerae with a selection of human gut commensal isolates. We show that the pathogen efficiently depleted representative genera of the Proteobacteria in vitro, while members of the Enterobacter cloacae complex and several Klebsiella species remained unaffected. We demonstrate that this resistance against T6SS assaults was mediated by the production of superior T6SS machinery or a barrier exerted by group I capsules. Collectively, our data provide new insights into immunity protein-independent T6SS resistance employed by the human microbiota and colonization resistance in general.
Mots-clé
Bacterial Capsules/immunology, Bacterial Capsules/metabolism, Cholera/immunology, Cholera/microbiology, Disease Resistance/immunology, Enterobacter cloacae/immunology, Enterobacter cloacae/metabolism, Gastrointestinal Microbiome/immunology, Humans, Klebsiella/immunology, Klebsiella/metabolism, Type VI Secretion Systems/metabolism, Vibrio cholerae/immunology, Vibrio cholerae/pathogenicity, Virulence Factors/immunology, Virulence Factors/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
12/10/2021 13:52
Dernière modification de la notice
08/08/2024 6:39