3-Dimensional Strain Analysis of Hypertrophic Cardiomyopathy: Insights From the NHLBI International HCM Registry.

Détails

ID Serval
serval:BIB_B915F4984D93
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
3-Dimensional Strain Analysis of Hypertrophic Cardiomyopathy: Insights From the NHLBI International HCM Registry.
Périodique
JACC. Cardiovascular imaging
Auteur⸱e⸱s
Heydari B., Satriano A., Jerosch-Herold M., Kolm P., Kim D.Y., Cheng K., Choi Y.L., Antiochos P., White J.A., Mahmod M., Chan K., Raman B., Desai M.Y., Ho C.Y., Dolman S.F., Desvigne-Nickens P., Maron M.S., Friedrich M.G., Schulz-Menger J., Piechnik S.K., Appelbaum E., Weintraub W.S., Neubauer S., Kramer C.M., Kwong R.Y.
Collaborateur⸱rice⸱s
HCMR Investigators
ISSN
1876-7591 (Electronic)
ISSN-L
1876-7591
Statut éditorial
Publié
Date de publication
04/2023
Peer-reviewed
Oui
Volume
16
Numéro
4
Pages
478-491
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Abnormal global longitudinal strain (GLS) has been independently associated with adverse cardiac outcomes in both obstructive and nonobstructive hypertrophic cardiomyopathy.
The goal of this study was to understand predictors of abnormal GLS from baseline data from the National Heart, Lung, and Blood Institute (NHLBI) Hypertrophic Cardiomyopathy Registry (HCMR).
The study evaluated comprehensive 3-dimensional left ventricular myocardial strain from cine cardiac magnetic resonance in 2,311 patients from HCMR using in-house validated feature-tracking software. These data were correlated with other imaging markers, serum biomarkers, and demographic variables.
Abnormal median GLS (> -11.0%) was associated with higher left ventricular (LV) mass index (93.8 ± 29.2 g/m <sup>2</sup> vs 75.1 ± 19.7 g/m <sup>2</sup> ; P < 0.0001) and maximal wall thickness (21.7 ± 5.2 mm vs 19.3 ± 4.1 mm; P < 0.0001), lower left (62% ± 9% vs 66% ± 7%; P < 0.0001) and right (68% ± 11% vs 69% ± 10%; P < 0.01) ventricular ejection fractions, lower left atrial emptying functions (P < 0.0001 for all), and higher presence and myocardial extent of late gadolinium enhancement (6 SD and visual quantification; P < 0.0001 for both). Elastic net regression showed that adjusted predictors of GLS included female sex, Black race, history of syncope, presence of systolic anterior motion of the mitral valve, reverse curvature and apical morphologies, LV ejection fraction, LV mass index, and both presence/extent of late gadolinium enhancement and baseline N-terminal pro-B-type natriuretic peptide and troponin levels.
Abnormal strain in hypertrophic cardiomyopathy is associated with other imaging and serum biomarkers of increased risk. Further follow-up of the HCMR cohort is needed to understand the independent relationship between LV strain and adverse cardiac outcomes in hypertrophic cardiomyopathy.
Mots-clé
United States, Humans, Female, Contrast Media, Gadolinium, National Heart, Lung, and Blood Institute (U.S.), Magnetic Resonance Imaging, Cine, Predictive Value of Tests, Cardiomyopathy, Hypertrophic, Ventricular Function, Left, Stroke Volume, Biomarkers, Registries, cardiac magnetic resonance, hypertrophic cardiomyopathy, late gadolinium enhancement, left ventricular hypertrophy, sarcomere, strain
Pubmed
Web of science
Création de la notice
23/01/2023 10:24
Dernière modification de la notice
08/06/2023 6:55
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