Protective role of NFATc2 in CD8+ long lived memory T cells in an allergy model : P234
Détails
ID Serval
serval:BIB_B8C7B61549EC
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Poster: résume de manière illustrée et sur une page unique les résultats d'un projet de recherche. Les résumés de poster doivent être entrés sous "Abstract" et non "Poster".
Collection
Publications
Institution
Titre
Protective role of NFATc2 in CD8+ long lived memory T cells in an allergy model : P234
Titre de la conférence
Abstracts of the Joint Annual Meeting of Immunology of the Austrian and German Societies (ÖGAI, DGfI)
Adresse
Vienna, September 3-6, 2008
ISBN
0043-5325
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
120
Série
Wiener Klinische Wochenschrift
Pages
130-131
Langue
anglais
Notes
The development of allergic immune responses is mediated by CD4+ effector T cells producing T helper 2 (Th2) cytokines as well as by CD8+ T cells that predominate over cytokines such as interferon-gamma (IFN-γ). However the role of IFN-γ in asthma is not fully understood. We demonstrate that mice
lacking nuclear factor of activated T cells-2 (NFATc2) developed increased airway hyperresponsiveness (AHR) and had increased serum IgE levels in the absence of exogenous allergen challenge. This AHR is associated with increased Th2 CD4+ T cell as well as CD8+ T cells defective in interferongamma (IFN-γ) and IL-2 production. Moreover, lung CD8+ T
cells from NFATc2 (-/-) mice contained increased numbers of CD8+ CD122+ CD127+ long lived memory T cells releasing increased amounts of interleukin-10 (IL-10). Adoptive transfer of ovalbumin (OVA) specific NFATc2 (-/-) CD8+ and NFATc2 (-/-) CD4+ T cells enhanced AHR and IL-17 levels while reducing IFN-γ in the airways of SCID reconstituted mice as compared
to those adoptively transferred with NFATc2(+/+)CD8+ and NFATc2 (-/-) CD4+ T cells . Interestingly, depletion of CD8+CD122+ T cells abrogated the increased AHR, eosinophils, and increased IFN-gamma observed in the BALF
of CD4+ NFATc2 (-/-) /CD8+ NFATc2 (-/-) T cell-reconstituted SCID mice. In conclusion NFATc2 expression in long lived memory CD8+ T cells controls directly the IFN-γ and IL-2 expression in CD8+ T cell, which then limits Th17 and Th2 development in the airways in this allergy model.
lacking nuclear factor of activated T cells-2 (NFATc2) developed increased airway hyperresponsiveness (AHR) and had increased serum IgE levels in the absence of exogenous allergen challenge. This AHR is associated with increased Th2 CD4+ T cell as well as CD8+ T cells defective in interferongamma (IFN-γ) and IL-2 production. Moreover, lung CD8+ T
cells from NFATc2 (-/-) mice contained increased numbers of CD8+ CD122+ CD127+ long lived memory T cells releasing increased amounts of interleukin-10 (IL-10). Adoptive transfer of ovalbumin (OVA) specific NFATc2 (-/-) CD8+ and NFATc2 (-/-) CD4+ T cells enhanced AHR and IL-17 levels while reducing IFN-γ in the airways of SCID reconstituted mice as compared
to those adoptively transferred with NFATc2(+/+)CD8+ and NFATc2 (-/-) CD4+ T cells . Interestingly, depletion of CD8+CD122+ T cells abrogated the increased AHR, eosinophils, and increased IFN-gamma observed in the BALF
of CD4+ NFATc2 (-/-) /CD8+ NFATc2 (-/-) T cell-reconstituted SCID mice. In conclusion NFATc2 expression in long lived memory CD8+ T cells controls directly the IFN-γ and IL-2 expression in CD8+ T cell, which then limits Th17 and Th2 development in the airways in this allergy model.
Web of science
Création de la notice
15/10/2009 8:43
Dernière modification de la notice
20/08/2019 16:26
Données d'usage
