Comparative haemodynamic and respiratory effects of midazolam and flunitrazepam as induction agents in cardiac surgery

Détails

ID Serval
serval:BIB_B8A647A18E39
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Comparative haemodynamic and respiratory effects of midazolam and flunitrazepam as induction agents in cardiac surgery
Périodique
Arzneimittel-Forschung
Auteur(s)
Morel  D., Forster  A., Gardaz  J. P., Suter  P. M., Gemperle  M.
ISSN
0004-4172 (Print)
Statut éditorial
Publié
Date de publication
1981
Volume
31
Numéro
12a
Pages
2264-7
Notes
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Résumé
30 cardiac surgical patients were investigated for comparing the respiratory and haemodynamic repercussions of induction of anaesthesia with either flunitrazepam or 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a] [1,4]benzodiazepine (midazolam, Ro 21-3981, Dormicum). The patients were premedicated with morphine, 0.15 mg/kg i.m., and divided into two groups: one group receiving flunitrazepam 0.03 mg/kg, the other midazolam 0.15 mg/kg injected i.v. over a 15-s period. The induction time and the respiratory depression were similar in both groups. A similar decrease in systolic, diastolic and mean arterial pressures was noted, with maximum decrease of mean arterial pressure of 21% 5 min after injection of flunitrazepam, and of 19% after injection of midazolam. Midazolam produced a significant but transient pulse acceleration of 4% 1 min after the injection, while flunitrazepam produced a moderate decrease of the heart rate. These results indicate that in cardiac surgical patients midazolam produces a moderate respiratory and cardiovascular depression similar to flunitrazepam.
Mots-clé
Adult Aged *Anesthetics Anti-Anxiety Agents/*pharmacology Benzodiazepines/*pharmacology Blood Gas Analysis *Cardiac Surgical Procedures Female Flunitrazepam/*pharmacology Hemodynamic Processes/*drug effects Humans Male Midazolam Middle Aged Respiration/*drug effects
Pubmed
Web of science
Création de la notice
28/01/2008 10:48
Dernière modification de la notice
20/08/2019 15:26
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