Effect of age and gender on citalopram and desmethylcitalopram steady-state plasma concentrations in adults and elderly depressed patients.

Détails

ID Serval
serval:BIB_B89A5097AC12
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effect of age and gender on citalopram and desmethylcitalopram steady-state plasma concentrations in adults and elderly depressed patients.
Périodique
Progress in neuro-psychopharmacology & biological psychiatry
Auteur⸱e⸱s
de Mendonça Lima C.A., Baumann P., Brawand-Amey M., Brogli C., Jacquet S., Cochard N., Powell-Golay K., Eap C.B.
ISSN
0278-5846
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
29
Numéro
6
Pages
952-6
Langue
anglais
Notes
Publication types: Clinical Trial ; Comparative Study ; Controlled Clinical Trial ; Journal Article - Publication Status: ppublish
Résumé
The effect of aging on steady-state plasma concentrations of citalopram (CIT) and desmethylcitalopram (DCIT) was investigated in 128 depressive patients treated with 10-80 mg/day CIT. They were separated into three groups, with age up to 64 years (mean age+/-S.D.: 47+/-12 years; n=48), between 65 and 79 years (72+/-1 years; n=57), and from 80 years or older (84+/-1 years; n=23). Body mass index (BMI), renal and hepatic functions were similar in the three groups. A large interindividual variability of plasma levels of CIT (16-fold) and DCIT (12-fold) was measured for a given dose. The mean plasma levels of CIT corrected for a 20 mg daily dose were 55% higher in the very elderly (>=80 years) patients (65+/-30 ng/ml; p<0.001) and 38% higher in the elderly (65-79 years) patients (58+/-24 ng/ml; p<0.001) when compared to the adult patients (42+/-17 ng/ml). DCIT mean plasma level was 38% higher (p<0.05) in the group of very elderly patients (22+/-10 ng/ml) when compared to the adult patients (16+/-9 ng/ml). As a consequence, the mean plasma concentration of CIT+DCIT was 48% higher in the very elderly patients (86+/-36 ng/ml; p<0.001) and 33% higher in the elderly patients (77+/-28 ng/ml; p<0.001) when compared to the adult patients (58+/-21 ng/ml). Age correlated significantly with CIT (r=0.43, p<0.001), DCIT (r=0.28, p<0.01), and CIT+DCIT plasma levels (r=0.44, p<0.001), and thus accounts for 18% of the variability of CIT plasma levels, with no influence of gender. The recommended dose reduction of CIT in elderly patients seems therefore justified.
Mots-clé
Aged, Aged, 80 and over, Aging, Antidepressive Agents, Citalopram, Depression, Dose-Response Relationship, Drug, Female, Gas Chromatography-Mass Spectrometry, Humans, Imipramine, Male, Middle Aged, Retrospective Studies, Sex Characteristics
Pubmed
Création de la notice
10/03/2008 10:53
Dernière modification de la notice
20/08/2019 15:26
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