Antibody-mediated and cellular immune responses induced in naive volunteers by vaccination with long synthetic peptides derived from the Plasmodium vivax circumsporozoite protein.

Détails

ID Serval
serval:BIB_B879968D032D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Antibody-mediated and cellular immune responses induced in naive volunteers by vaccination with long synthetic peptides derived from the Plasmodium vivax circumsporozoite protein.
Périodique
American Journal of Tropical Medicine and Hygiene
Auteur⸱e⸱s
Arévalo-Herrera M., Soto L., Perlaza B.L., Céspedes N., Vera O., Lenis A.M., Bonelo A., Corradin G., Herrera S.
ISSN
1476-1645 (Electronic)
ISSN-L
0002-9637
Statut éditorial
Publié
Date de publication
2011
Volume
84
Numéro
2 Suppl
Pages
35-42
Langue
anglais
Résumé
Plasmodium vivax circumsporozoite (CS) protein is a leading malaria vaccine candidate. We describe the characterization of specific immune responses induced in 21 malaria-naive volunteers vaccinated with long synthetic peptides derived from the CS protein formulated in Montanide ISA 720. Both antibody- and cell-mediated immune responses were analyzed. Antibodies were predominantly of IgG1 and IgG3 isotypes, recognized parasite proteins on the immunofluorescent antibody test, and partially blocked sporozoite invasion of hepatoma cell lines in vitro. Peripheral blood mononuclear cells from most volunteers (94%) showed IFN-γ production in vitro upon stimulation with both long signal peptide and short peptides containing CD8+ T-cell epitopes. The relatively limited sample size did not allow conclusions about HLA associations with the immune responses observed. In summary, the inherent safety and tolerability together with strong antibody responses, invasion blocking activity, and the IFN-γ production induced by these vaccine candidates warrants further testing in a phase II clinical trial.
Mots-clé
Adolescent, Adult, Antibodies, Protozoan/blood, Female, Humans, Immunity, Cellular/physiology, Malaria Vaccines/immunology, Malaria, Vivax/immunology, Malaria, Vivax/prevention & control, Male, Plasmodium vivax/immunology, Protozoan Proteins/immunology, Vaccination, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/10/2011 14:54
Dernière modification de la notice
20/08/2019 16:26
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