Clinical Implications of CD8+ T-cell infiltration in frequent and rare cancers.

Détails

ID Serval
serval:BIB_B86E1BCCAF3F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Editorial
Collection
Publications
Institution
Titre
Clinical Implications of CD8+ T-cell infiltration in frequent and rare cancers.
Périodique
Journal of Investigative Dermatology
Auteur⸱e⸱s
Feldmeyer L., Gaide O., Speiser D.E.
ISSN
1523-1747 (Electronic)
ISSN-L
0022-202X
Statut éditorial
Publié
Date de publication
2013
Volume
133
Numéro
8
Pages
1929-1932
Langue
anglais
Notes
Publication types: Comment ; Journal Article Publication Status: ppublishDocument Type: Editorial Material
Résumé
Recent studies of cancer patients revealed high diversity in oncogenic mechanisms, leading to increased treatment individualization for subgroups of patients with frequent cancers. A similar development may not be possible for patients with rare cancers, such as Merkel cell carcinoma (MCC). Finding shared disease mechanisms may open new options to understanding and treating such tumors. Tumor-infiltrating CD8+ T cells are frequently associated with favorable clinical outcome in a remarkably large spectrum of cancers. In this issue, Afanasiev et al. suggest a mechanism that may hinder the tumor homing of CD8+ T cells in MCC patients. It is possible that therapeutic mobilization of anti-cancer T cells may be useful in patients who share this specific immune biological feature.
Mots-clé
CD8-Positive T-Lymphocytes/immunology, Carcinoma, Merkel Cell/immunology, Carcinoma, Merkel Cell/pathology, E-Selectin/immunology, Female, Humans, Male, Skin Neoplasms/immunology, Skin Neoplasms/pathology
Pubmed
Web of science
Open Access
Oui
Création de la notice
30/10/2013 11:00
Dernière modification de la notice
20/08/2019 15:26
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