Role of the renal circadian timing system in maintaining water and electrolytes homeostasis.

Détails

Ressource 1Télécharger: BIB_B81E53EE97B7.P001.pdf (344.07 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_B81E53EE97B7
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Role of the renal circadian timing system in maintaining water and electrolytes homeostasis.
Périodique
Molecular and Cellular Endocrinology
Auteur(s)
Firsov D., Tokonami N., Bonny O.
ISSN
1872-8057 (Electronic)
ISSN-L
0303-7207
Statut éditorial
Publié
Date de publication
2012
Volume
349
Numéro
1
Pages
51-55
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Many basic physiological functions exhibit circadian rhythmicity. These functional rhythms are driven, in part, by the circadian clock, an ubiquitous molecular mechanism allowing cells and tissues to anticipate regular environmental events and to prepare for them. This mechanism has been shown to play a particularly important role in maintaining stability (homeostasis) of internal conditions. Because the homeostatic equilibrium is continuously challenged by environmental changes, the role of the circadian clock is thought to consist in the anticipative adjustment of homeostatic pathways in relation with the 24h environmental cycle. The kidney is the principal organ responsible for the regulation of the composition and volume of extracellular fluids (ECF). Several major parameters of kidney function, including renal plasma flow (RPF), glomerular filtration rate (GFR) and tubular reabsorption and secretion have been shown to exhibit strong circadian oscillations. Recent evidence suggest that the circadian clock can be involved in generation of these rhythms through external circadian time cues (e.g. humoral factors, activity and body temperature rhythms) or, trough the intrinsic renal circadian clock. Here, we discuss the role of renal circadian mechanisms in maintaining homeostasis of water and three major ions, namely, Na(+), K(+) and Cl(-).
Mots-clé
Animals, Chlorides/metabolism, Circadian Clocks, Circadian Rhythm, Homeostasis, Hormones/metabolism, Humans, Kidney/metabolism, Kidney/physiology, Potassium/metabolism, Sodium/metabolism, Water/metabolism, Water-Electrolyte Balance
Pubmed
Web of science
Open Access
Oui
Création de la notice
19/03/2012 18:57
Dernière modification de la notice
20/10/2020 10:08
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