Rétinopathie du prématuré: étude rétrospective sur une période de dix ans au CHU de Strasbourg [Retinopathy of prematurity: 10-year retrospective study at the University Hospital of Strasbourg].

Détails

ID Serval
serval:BIB_B80314EE62CF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Rétinopathie du prématuré: étude rétrospective sur une période de dix ans au CHU de Strasbourg [Retinopathy of prematurity: 10-year retrospective study at the University Hospital of Strasbourg].
Périodique
Archives de Pédiatrie
Auteur(s)
Gaugler C., Beladdale J., Astruc D., Schaeffer D., Donato L., Speeg-Schatz C., Siméoni U., Messer J.
ISSN
0929-693X (Print)
ISSN-L
0929-693X
Statut éditorial
Publié
Date de publication
2002
Peer-reviewed
Oui
Volume
9
Numéro
4
Pages
350-357
Langue
français
Notes
Publication types: English Abstract ; Journal Article Publication Status: ppublish
Résumé
OBJECTIVES: This work was splitted in two parts: the first one was the study of retinopathy incidence in premature infants less than 33 weeks gestation, born between 1988 and 1997; the second one is the identification of severe retinopathy different risk factors.
PATIENTS AND METHODS: Our study was retrospective over ten years. All premature infants less than 33 weeks gestation born between January 1, 1988 and December 31 1997, admitted to the Strasbourg neonatal intensive care unit with retinopathy, were included (164 children). First we studied the incidence evolution of retinopathy over these ten years; then by a statistical study (univaried and multivaried) we looked for a significant difference for several factors between the infants with mild retinopathy and the group with severe ocular disease.
RESULTS: Retinopathy incidence decreased in ten years from 13.7 to 6.7% for the moderate forms (P < 0.001) and from 3.7 to 1.7% for severe stage (non significant). A significant difference was found for various factors after comparison between both groups. The birth weight (P = 5 x 10(-4)), the gestational age (P = 4 x 10(-6)), were weaker in the group with severe retinopathy. A maternofetal or nosocomial infection (P = 0.009; P = 0.002), hemodynamic shock (P = 10(-6)), patent ductus arteriosus (P = 10(-6)), bronchopulmonary dysplasia (P = 3 x 10(-6)), postnatal steroid treatment (P = 0.007), respiratory distress syndrome (P = 0.01), were all more frequent in the severe retinopathy sample. The number of days with oxygenotherapy (P = 10(-6)) and mechanical ventilation (P = 10(-6)) the number of blood transfusion (P = 10(-5)) were higher in this group than in the other. The logistic regression analysis showed that the hemodynamic parameters influence mostly on the risk of severe ocular disease, like an hemodynamic shock syndrome (OR = 16.94; CI = 2.12-135.77) or a patent ductus arteriosus (OR = 5.36; CI = 1.53-18.74).
CONCLUSION: A decrease of the retinopathy incidence in premature infants was observed in ten years, probably due to better care in the neonatal period. An unstable hemodynamic state would be one prominent risk factor in the genesis of severe retinopathy of prematurity.
Mots-clé
Blood Transfusion, Cross Infection, Female, Hemodynamics, Humans, Incidence, Infant, Newborn, Infant, Premature, Infant, Very Low Birth Weight, Male, Oxygen Inhalation Therapy, Respiration, Artificial, Retinopathy of Prematurity/epidemiology, Retinopathy of Prematurity/etiology, Retrospective Studies, Risk Factors, Shock/complications, Steroids/adverse effects
Pubmed
Web of science
Création de la notice
22/02/2015 9:29
Dernière modification de la notice
20/08/2019 15:26
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