Hashimoto's myoclonic encephalopathy: an underdiagnosed treatable condition?

Détails

ID Serval
serval:BIB_B7E03965DC7F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Hashimoto's myoclonic encephalopathy: an underdiagnosed treatable condition?
Périodique
Movement Disorders
Auteur(s)
Ghika-Schmid F., Ghika J., Regli F., Dworak N., Bogousslavsky J., Städler C., Portmann L., Despland P.A.
ISSN
0885-3185 (Print)
ISSN-L
0885-3185
Statut éditorial
Publié
Date de publication
1996
Volume
11
Numéro
5
Pages
555-562
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article ; Review
Publication Status: ppublish
Résumé
We report two patients with subacute diffuse encephalopathy characterized by confusion, myoclonic encephalopathy, and mild akineto-rigid extrapyramidal signs in one case and by apathy, memory deficit, and partial complex seizures in the other. Hashimoto's thyroiditis with high titers of anti-thyroglobulin antibodies was diagnosed in both patients, who were unresponsive to anticonvulsant medication, but showed rapid neurological improvement following steroid treatment. On neuropsychological examination, predominant frontotemporal dysfunction was noted. Electroencephalographic activity was remarkable for its rhythmical delta activity, unresponsive to, or even paradoxically increased by, anticonvulsant treatment. On magnetic resonance imaging, atrophy with temporal predominance was found. These observations support the idea that this potentially treatable dementia and movement disorder should be classified as a separate clinical entity.
Mots-clé
Adult, Aged, Anti-Inflammatory Agents/administration & dosage, Anti-Inflammatory Agents/therapeutic use, Anticonvulsants/administration & dosage, Anticonvulsants/therapeutic use, Brain/physiopathology, Clonazepam/administration & dosage, Clonazepam/therapeutic use, Cognition Disorders/diagnosis, Electroencephalography, Extrapyramidal Tracts/physiopathology, Female, Frontal Lobe/physiopathology, Humans, Methylprednisolone/administration & dosage, Methylprednisolone/therapeutic use, Myoclonus/drug therapy, Myoclonus/physiopathology, Neuropsychological Tests, Prednisone/administration & dosage, Prednisone/therapeutic use, Temporal Lobe/physiopathology, Thyroiditis, Autoimmune/diagnosis, Thyroiditis, Autoimmune/drug therapy, Thyrotropin/secretion
Pubmed
Web of science
Création de la notice
25/01/2008 11:40
Dernière modification de la notice
20/08/2019 15:25
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