The preventive properties of antiretrovirals have been recognized for many years, and pre-exposure prophylaxis (PrEP) has been used in Switzerland since 2016 to prevent HIV acquisition by HIV-negative people. The aim of this article is to provide an overview of PrEP uses in French-speaking Switzerland from the experience of users of this preventive drug. The main results of our research highlight the existence of two experiential versions of PrEP, i.e. subjective definitions shared by the people concerned by the indication. The first version relates to the effects of PrEP on anxiety, where taking a preventive drug drastically reduces the fear of contamination, and the second version relates to the capacity of the drug to modulate trust between individuals.