Limited CD4+ T-cell renewal in early HIV-1 infection: effect of highly active antiretroviral therapy.
Détails
ID Serval
serval:BIB_B77754D94784
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Limited CD4+ T-cell renewal in early HIV-1 infection: effect of highly active antiretroviral therapy.
Périodique
Nature Medicine
ISSN
1078-8956
Statut éditorial
Publié
Date de publication
1998
Peer-reviewed
Oui
Volume
4
Numéro
7
Pages
794-801
Langue
anglais
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Jul
Résumé
We show that the fraction of proliferating CD4+ lymphocytes is similar in HIV-infected subjects in the early stage of disease and in HIV-negative subjects, whereas the fraction of proliferating CD8+ lymphocytes is increased 6.8-fold in HIV-infected subjects. After initiation of antiviral therapy, there is a late increase in proliferating CD4+ T cells associated with the restoration of CD4+ T-cell counts. These results provide strong support for the idea of limited CD4+ T-cell renewal in the early stage of HIV infection and indicate that after effective suppression of virus replication, the mechanisms of CD4+ T-cell production are still functional in early HIV infection.
Mots-clé
Adult, Aged, Anti-HIV Agents, CD4-CD8 Ratio, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Carbamates, Cell Division, Dideoxynucleosides, Drug Therapy, Combination, Female, HIV Infections, HIV Protease Inhibitors, Humans, Ki-67 Antigen, Lymph Nodes, Male, Middle Aged, Reverse Transcriptase Inhibitors, Sulfonamides
Pubmed
Web of science
Création de la notice
28/01/2008 9:59
Dernière modification de la notice
20/08/2019 16:25