Effects of muscarinic blockade on the thermic effect of oral or intravenous carbohydrate.

Détails

ID Serval
serval:BIB_B75406D48D56
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effects of muscarinic blockade on the thermic effect of oral or intravenous carbohydrate.
Périodique
European Journal of Applied Physiology and Occupational Physiology
Auteur⸱e⸱s
Schneeberger D., Tappy L., Temler E., Jeanprêtre N., Jéquier E.
ISSN
0301-5548
Statut éditorial
Publié
Date de publication
1991
Peer-reviewed
Oui
Volume
63
Numéro
3-4
Pages
242-249
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Muscarinic blockade by atropine has been shown to decrease the thermic effect of a mixed meal, but not of intravenous glucose. To further delineate the mechanisms involved in the atropine-induced inhibition of thermogenesis after a meal, plasma substrate and hormone concentrations, energy expenditure (EE) and substrate oxidation rates were measured before and during a continuous glucose infusion (44.4 mumol.kg-1.min-1) with or without atropine. After 2 h of glucose infusion, a 20-g oral fructose load was administered while the glucose infusion was continued. Plasma insulin concentrations attained a plateau at 596 (SEM 100) pmol.l-1 after 120 min of glucose infusion and were not affected by muscarinic blockade; plasma glucose concentrations peaked at 13.3 (SEM 0.5) mmol.l-1 at 90 min and decreased progressively thereafter; no difference was observed with or without atropine. Plasma free fatty acid and glucagon concentrations, with or without atropine, were both decreased to 201 (SEM 18) mumol.l-1 and 74 (SEM 4) ng.l-1, respectively, after 2 h of glucose infusion, and were not further suppressed after oral fructose. Carbohydrate oxidation rates (CHO(ox)) increased to 20.8 (SEM 1.4) mumol.kg-1.min-1 and lipid oxidation rates (Lox) decreased to 1.5 (SEM 0.3) mumol.kg-1.min-1 between 90 and 120 min after the beginning of glucose infusion and were not affected by atropine. Glucose-induced thermogenesis was similar with [6.5% (SEM 1.4%) of basal EE] or without [6.0% (SEM 1.0%), NS) muscarinic blockade during the 30 min preceding fructose ingestion.(ABSTRACT TRUNCATED AT 250 WORDS)
Mots-clé
Administration, Oral, Adult, Atropine/pharmacology, Blood Glucose/drug effects, Blood Glucose/metabolism, Body Temperature Regulation/drug effects, C-Peptide/metabolism, Energy Metabolism/drug effects, Fatty Acids, Nonesterified/blood, Female, Fructose/administration &amp, dosage, Fructose/pharmacology, Glucagon/blood, Humans, Injections, Intravenous, Insulin/blood, Male, Parasympatholytics/pharmacology, Pulmonary Gas Exchange/drug effects
Pubmed
Web of science
Création de la notice
24/01/2008 14:36
Dernière modification de la notice
20/08/2019 16:25
Données d'usage