An update on the search for a Plasmodium vivax vaccine

Détails

ID Serval
serval:BIB_B742D5E848CE
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
An update on the search for a Plasmodium vivax vaccine
Périodique
Trends in Parasitology
Auteur(s)
Herrera  S., Corradin  G., Arevalo-Herrera  M.
ISSN
1471-4922 (Print)
Statut éditorial
Publié
Date de publication
03/2007
Volume
23
Numéro
3
Pages
122-8
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Mar
Résumé
Although Plasmodium falciparum is the leading cause of morbidity and mortality due to malaria worldwide, nearly 2.5 billion people, mostly outside Africa, are also at risk from malaria caused by Plasmodium vivax infection. Currently, almost all efforts to develop a malaria vaccine have focused on P. falciparum. For example, there are 23 P. falciparum vaccine candidates undergoing advanced clinical studies and only two P. vivax vaccine candidates being tested in preliminary (Phase I) clinical trials, with few others being assessed in preclinical studies. More investment and a greater effort toward the development of P. vivax vaccine components for a multi-species vaccine are required. This is mainly because of the wide geographical coexistence of both parasite species but also because of increasing drug resistance, recent observations of severe and lethal P. vivax cases and relapsing parasite behaviour. Availability of the P. vivax genome has contributed to antigen discovery but new means to test vaccines in future trials remain to be designed.
Mots-clé
Animals Antigens, Protozoan/*immunology Humans *Malaria Vaccines Malaria, Vivax/*prevention & control Merozoite Surface Protein 1/immunology Plasmodium vivax/*immunology Protozoan Proteins/*immunology Receptors, Cell Surface/immunology Species Specificity
Pubmed
Web of science
Création de la notice
24/01/2008 14:55
Dernière modification de la notice
20/08/2019 15:25
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