Increased brain perfusion contrast with T2 -prepared intravoxel incoherent motion (T2prep IVIM) MRI.

Détails

ID Serval
serval:BIB_B6EDC0F03ED6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Increased brain perfusion contrast with T2 -prepared intravoxel incoherent motion (T2prep IVIM) MRI.
Périodique
Nmr in Biomedicine
Auteur⸱e⸱s
Federau C., O'Brien K.
ISSN
1099-1492 (Electronic)
ISSN-L
0952-3480
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
28
Numéro
1
Pages
9-16
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
The feasibility to measure brain perfusion using intravoxel incoherent motion (IVIM) MRI has been reported recently with currently clinically available technology. The method is intrinsically local and quantitative, but is contaminated by partial volume effects with cerebrospinal fluid (CSF). Signal from CSF can be suppressed by a 180° inversion recovery (180°-IR) magnetization preparation, but this also leads to strong suppression of blood and brain tissue signal. Here, we take advantage of the different T2 relaxations of blood and brain relative to CSF, and implement a T2 -prepared IVIM (T2prep IVIM) inversion recovery acquisition, which permits a recovery of between 43% and 57% of arterial and venous blood magnetization at excitation time compared with the theoretical recovery of between 27% and 30% with a standard 180°-IR. We acquired standard IVIM (IVIM), T2prep IVIM and dynamic susceptibility contrast (DSC) images at 3 T using a 32-multichannel receiver head coil in eight patients with known large high-grade brain tumors. We compared the contrast and contrast-to-noise ratio obtained in the corresponding cerebral blood volume images quantitatively, as well as subjectively by two neuroradiologists. Our findings suggest that quantitative cerebral blood volume contrast and contrast-to-noise ratio, as well as subjective lesion detection, contrast quality and diagnostic confidence, are increased with T2prep IVIM relative to IVIM and DSC.
Pubmed
Web of science
Création de la notice
09/01/2015 21:05
Dernière modification de la notice
20/08/2019 16:25
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