Tissue-Specific Evolution of Protein Coding Genes in Human and Mouse.

Détails

Ressource 1Télécharger: BIB_B6BE63795D1F.P001.pdf (2685.66 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_B6BE63795D1F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Tissue-Specific Evolution of Protein Coding Genes in Human and Mouse.
Périodique
Plos One
Auteur⸱e⸱s
Kryuchkova-Mostacci N., Robinson-Rechavi M.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
10
Numéro
6
Pages
e0131673
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Protein-coding genes evolve at different rates, and the influence of different parameters, from gene size to expression level, has been extensively studied. While in yeast gene expression level is the major causal factor of gene evolutionary rate, the situation is more complex in animals. Here we investigate these relations further, especially taking in account gene expression in different organs as well as indirect correlations between parameters. We used RNA-seq data from two large datasets, covering 22 mouse tissues and 27 human tissues. Over all tissues, evolutionary rate only correlates weakly with levels and breadth of expression. The strongest explanatory factors of purifying selection are GC content, expression in many developmental stages, and expression in brain tissues. While the main component of evolutionary rate is purifying selection, we also find tissue-specific patterns for sites under neutral evolution and for positive selection. We observe fast evolution of genes expressed in testis, but also in other tissues, notably liver, which are explained by weak purifying selection rather than by positive selection.
Mots-clé
Animals, Databases, Nucleic Acid, Evolution, Molecular, Gene Duplication, Gene Regulatory Networks, Genomics/methods, Humans, Mice, Open Reading Frames, Organ Specificity/genetics, Selection, Genetic
Pubmed
Web of science
Open Access
Oui
Création de la notice
16/06/2015 7:11
Dernière modification de la notice
20/08/2019 15:25
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