Idiopathic granulomatosis manifesting as fever of unknown origin
Détails
ID Serval
serval:BIB_B6B590E04492
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Idiopathic granulomatosis manifesting as fever of unknown origin
Périodique
Mayo Clinic Proceedings
ISSN
0025-6196 (Print)
Statut éditorial
Publié
Date de publication
01/1989
Volume
64
Numéro
1
Pages
44-50
Notes
Journal Article --- Old month value: Jan
Résumé
Twenty patients with fever of unknown origin were found to have idiopathic granulomatosis of the liver, lymph nodes, spleen, or bone marrow. At the time of initial examination, these patients had persistent or recurrent fever and pronounced constitutional symptoms but few physical findings. The most common laboratory abnormalities were increased erythrocyte sedimentation rate in 18, abnormal results of liver function tests in 12, anemia in 11, and hypergammaglobulinemia in 10. Of the 20 patients, 14 required corticosteroids at the beginning of the illness for control of symptoms, especially fever. After 5 to 10 years of follow-up, an alternative diagnosis had been established in 5 of the 20 patients. Of the remaining 15 patients with fever and idiopathic granulomatosis, 6 are still receiving corticosteroids. Corticosteroid treatment did not result in progression or dissemination of an unrecognized infection. No clinical or laboratory abnormality helped to predict the need for long-term corticosteroid treatment.
Mots-clé
Adult
Aged
Bone Marrow Diseases/complications
Female
Fever of Unknown Origin/drug therapy/*etiology
Follow-Up Studies
Glucocorticoids/therapeutic use
Granuloma/*complications
Humans
Liver Diseases/complications
Lymphadenitis/complications
Male
Middle Aged
Retrospective Studies
Splenic Diseases/complications
Pubmed
Web of science
Création de la notice
25/01/2008 15:46
Dernière modification de la notice
20/08/2019 16:25