Microbes and asthma: Opportunities for intervention.

Détails

ID Serval
serval:BIB_B6ADBC1C07C3
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Microbes and asthma: Opportunities for intervention.
Périodique
Journal of Allergy and Clinical Immunology
Auteur⸱e⸱s
Smits H.H., Hiemstra P.S., Prazeres da Costa C., Ege M., Edwards M., Garn H., Howarth P.H., Jartti T., de Jong E.C., Maizels R.M., Marsland B.J., McSorley H.J., Müller A., Pfefferle P.I., Savelkoul H., Schwarze J., Unger W.W., von Mutius E., Yazdanbakhsh M., Taube C.
ISSN
1097-6825 (Electronic)
ISSN-L
0091-6749
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
137
Numéro
3
Pages
690-697
Langue
anglais
Résumé
The worldwide incidence and prevalence of asthma continues to increase. Asthma is now understood as an umbrella term for different phenotypes or endotypes, which arise through different pathophysiologic pathways. Understanding the many factors contributing to development of the disease is important for the identification of novel therapeutic targets for the treatment of certain asthma phenotypes. The hygiene hypothesis has been formulated to explain the increasing prevalence of allergic disease, including asthma. This hypothesis postulates that decreased exposure at a young age to certain infectious agents as a result of improved hygiene, increased antibiotic use and vaccination, and changes in lifestyle and dietary habits is associated with changes in the immune system, which predispose subjects to allergy. Many microbes, during their coevolution with human subjects, developed mechanisms to manipulate the human immune system and to increase their chances of survival. Improving models of asthma, as well as choosing adequate end points in clinical trials, will lead to a more complete understanding of the underlying mechanisms, thus providing an opportunity to devise primary and secondary interventions at the same time as identifying new molecular targets for treatment. This article reports the discussion and conclusion of a workshop under the auspices of the Netherlands Lung Foundation to extend our understanding of how modulation of the immune system by bacterial, parasitic, and viral infections might affect the development of asthma and to map out future lines of investigation.
Pubmed
Web of science
Création de la notice
10/03/2016 18:22
Dernière modification de la notice
20/08/2019 15:24
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