Successful prophylaxis against experimental streptococcal endocarditis with bacteriostatic antibiotics

Détails

ID Serval
serval:BIB_B69054DEB03A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Successful prophylaxis against experimental streptococcal endocarditis with bacteriostatic antibiotics
Périodique
Journal of Infectious Diseases
Auteur(s)
Glauser  M. P., Francioli  P.
ISSN
0022-1899 (Print)
Statut éditorial
Publié
Date de publication
12/1982
Volume
146
Numéro
6
Pages
806-10
Notes
Journal Article --- Old month value: Dec
Résumé
Because bacteriostatic concentrations of vancomycin are effective in prophylaxis against endocarditis due to Streptococcus sanguis in rats, the efficacy of three other bacteriostatic antibiotics was investigated against three different streptococcal species that cause subacute endocarditis in humans: Streptococcus intermedius. S. sanguis, and Streptococcus mitior. Rats were challenged by intravenous injection of 2 x 10(5) colony-forming units of streptococci 24 hr after intracardiac insertion of a transaortic catheter and 30 min after intravenous injection of various doses of clindamycin, erythromycin, and doxycycline. Significant protection was achieved with all three antibiotics, but only clindamycin was fully effective against all three species at doses that simulated serum levels achievable in humans after oral administration. Endocarditis was prevented by antibiotic concentrations in serum far below minimal bactericidal concentrations for these streptococci. Furthermore, serum at the time of bacterial challenge was not bactericidal. Therefore, single doses of nonbactericidal antibiotics prevented endocarditis in rats by mechanisms other than bacterial killing.
Mots-clé
Animals Clindamycin/blood/*therapeutic use Doxycycline/blood/*therapeutic use Endocarditis, Bacterial/*prevention & control Erythromycin/blood/*therapeutic use Female Rats Rats, Inbred Strains Streptococcal Infections/*prevention & control Streptococcus/drug effects Streptococcus sanguis/drug effects
Pubmed
Web of science
Création de la notice
25/01/2008 18:08
Dernière modification de la notice
20/08/2019 16:24
Données d'usage