Site of the action of a synthetic atrial natriuretic peptide evaluated in humans.

Détails

ID Serval
serval:BIB_B65D518F86EC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Site of the action of a synthetic atrial natriuretic peptide evaluated in humans.
Périodique
Kidney International
Auteur(s)
Biollaz J., Bidiville J., Diézi J., Waeber B., Nussberger J., Brunner-Ferber F., Gomez H.J., Brunner H.R.
ISSN
0085-2538 (Print)
ISSN-L
0085-2538
Statut éditorial
Publié
Date de publication
1987
Peer-reviewed
Oui
Volume
32
Numéro
4
Pages
537-546
Langue
anglais
Notes
Publication types: Clinical Trial ; Controlled Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The renal site of the natriuretic effect of human, atrial natriuretic peptide (hANP) was studied using clearance techniques in eight salt-loaded normal volunteers undergoing maximal water diuresis. Lithium was used as a marker of proximal sodium reabsorption. According to a two-way, single blind, crossover design, hANP (Met12-(3-28)-eicosahexapeptide, (2 micrograms/min) or its vehicle (Ve) were infused for two hours, followed by a two-hour recovery period. Blood pressure, heart rate and insulin clearance remained unchanged. During hANP infusion, the filtration fraction increased slightly from 19.6 to 24.3% (P less than 0.001), fractional water excretion rose transiently at the beginning of the infusion. Fractional excretion of sodium increased markedly from 2.2% to 7.4% (P less than 0.001) but remained unchanged with Ve. ANP increased fractional excretion of lithium slightly from 46 to 58% (P less than 0.01), while it remained stable at 47% during Ve. The distal tubular rejection fraction of sodium calculated from sodium and lithium clearances rose markedly from 4.7 to 13% (P less than 0.001) and returned to 6.2% at the end of the recovery period. Thus, under salt loading and water diuresis conditions, hANP infusion did not alter GFR, but reduced proximal reabsorption of sodium, and markedly enhanced the fraction of sodium escaping distal tubular reabsorption, suggesting that hANP-induced natriuresis is due, for an important part, to inhibition of sodium reabsorption in the distal nephron.
Mots-clé
Adult, Atrial Natriuretic Factor/administration & dosage, Atrial Natriuretic Factor/pharmacology, Diuresis/drug effects, Eicosanoic Acids/administration & dosage, Eicosanoic Acids/pharmacology, Glomerular Filtration Rate/drug effects, Humans, Infusions, Intravenous, Kidney Tubules/drug effects, Kidney Tubules, Distal/drug effects, Kidney Tubules, Distal/metabolism, Kidney Tubules, Proximal/drug effects, Kidney Tubules, Proximal/metabolism, Lithium/pharmacokinetics, Lithium/urine, Male, Natriuresis/drug effects, Peptide Fragments/administration & dosage, Peptide Fragments/pharmacology, Renal Circulation/drug effects
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/01/2008 12:54
Dernière modification de la notice
20/08/2019 16:24
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