HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

Détails

ID Serval
serval:BIB_B62C0A9BDED5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease
Périodique
Nature
Auteur(s)
Pantaleo  G., Graziosi  C., Demarest  J. F., Butini  L., Montroni  M., Fox  C. H., Orenstein  J. M., Kotler  D. P., Fauci  A. S.
ISSN
0028-0836 (Print)
Statut éditorial
Publié
Date de publication
03/1993
Volume
362
Numéro
6418
Pages
355-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar 25
Résumé
Primary infection with the human immunodeficiency virus (HIV) is generally followed by a burst of viraemia with or without clinical symptoms. This in turn is followed by a prolonged period of clinical latency. During this period there is little, if any, detectable viraemia, the numbers of infected cells in the blood are very low, and it is extremely difficult to demonstrate virus expression in these cells. We have analysed viral burden and levels of virus replication simultaneously in the blood and lymphoid organs of the same individuals at various stages of HIV disease. Here we report that in early-stage disease there is a dichotomy between the levels of viral burden and virus replication in peripheral blood versus lymphoid organs. HIV disease is active in the lymphoid tissue throughout the period of clinical latency, even at times when minimal viral activity is demonstrated in blood.
Mots-clé
Acquired Immunodeficiency Syndrome/microbiology Adenoids/microbiology Adult Blood/microbiology Child, Preschool DNA, Viral Dendritic Cells/ultrastructure Female HIV Infections/*microbiology HIV Seropositivity/microbiology HIV-1/genetics/*growth & development Humans In Situ Hybridization Inclusion Bodies, Viral/ultrastructure Lymph Nodes/microbiology/pathology Lymphocytes/microbiology Lymphoid Tissue/*microbiology Male Microscopy, Electron Polymerase Chain Reaction Tonsil/microbiology
Pubmed
Web of science
Création de la notice
25/01/2008 15:58
Dernière modification de la notice
20/08/2019 16:24
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