Histological findings of a choroidal neovascular membrane removed at the time of macular translocation in a patient previously treated with intravitreal bevacizumab treatment (Avastin).

Détails

ID Serval
serval:BIB_B5E87F15508F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Histological findings of a choroidal neovascular membrane removed at the time of macular translocation in a patient previously treated with intravitreal bevacizumab treatment (Avastin).
Périodique
The British journal of ophthalmology
Auteur(s)
Gibran S.K., Sachdev A., Stappler T., Newsome R., Wong D., Hiscott P.
ISSN
0007-1161 (Print)
ISSN-L
0007-1161
Statut éditorial
Publié
Date de publication
05/2007
Peer-reviewed
Oui
Volume
91
Numéro
5
Pages
602-604
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Résumé
To report the findings in a patient treated by repeated intravitreal bevacizumab (Avastin) injections, followed by macular relocation and excision of subfoveal choroidal neovascular membrane (CNV).
Histopathological evaluation of the CNV specimen, including immunohistochemical assessment.
During surgical excision, the CNV seemed to be avascular and its underlying bed did not bleed. Histopathological examination revealed that the CNV comprised avascular fibrous subretinal tissue containing fibroblastic retinal pigment epithelial (RPE) cells, fragments of irregular thickened Bruch's membrane and fibrotic choroidal tissue containing some medium-sized vessels but no choriocapillaris.
The development of an RPE tear during the course of Avastin treatment may reflect contraction of the avascular subretinal tissue, whereas the lack of capillaries in both choroidal and subretinal components may be caused by the increased access of Avastin to the choriocapillaris in the presence of the RPE tear.
Mots-clé
Aged, Angiogenesis Inhibitors/administration & dosage, Antibodies, Monoclonal/administration & dosage, Antibodies, Monoclonal, Humanized, Bevacizumab, Choroidal Neovascularization/drug therapy, Choroidal Neovascularization/pathology, Choroidal Neovascularization/surgery, Drug Administration Routes, Humans, Macular Degeneration/drug therapy, Macular Degeneration/pathology, Macular Degeneration/surgery, Male
Pubmed
Web of science
Création de la notice
31/08/2018 8:43
Dernière modification de la notice
20/08/2019 16:24
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