Effect of ornithine on transferrin secretion of rat and human hepatocyte cultures.

Détails

ID Serval
serval:BIB_B5B083DCB5F6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effect of ornithine on transferrin secretion of rat and human hepatocyte cultures.
Périodique
Liver
Auteur(s)
Lescoat G., Loreal O., Desvergne B., Pasdeloup N., Deugnier Y., Brissot P.
ISSN
0106-9543[print], 0106-9543[linking]
Statut éditorial
Publié
Date de publication
12/1988
Volume
8
Numéro
6
Pages
360-365
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Fetal rat or neonatal human hepatocytes and a human hepatoma cell line were cultured in an arginine-free medium, supplemented or not with L-ornithine. This amino-acid improved survival of hepatocytes and strongly enhanced their transferrin secretion. Moreover, this increase observed in transferrin production was well correlated with a higher corresponding mRNA level. Thus, it may be postulated that the mechanism involved in the increased transferrin secretion by L-ornithine is of pretranslational origin.
Mots-clé
Animals, Cells, Cultured, Fetus, Humans, Liver/cytology, Ornithine/pharmacology, RNA, Messenger/metabolism, Rats, Transferrin/metabolism, Tumor Cells, Cultured
Pubmed
Web of science
Création de la notice
24/01/2008 16:26
Dernière modification de la notice
20/08/2019 16:24
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