Les corticosteroides inhales diminuent-ils la mortalite dans la bronchopneumopathie chronique obstructive? [Do inhaled corticosteroids reduce mortality in chronic obstructive pulmonary disease?]

Détails

ID Serval
serval:BIB_B56DAAC9AC05
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Les corticosteroides inhales diminuent-ils la mortalite dans la bronchopneumopathie chronique obstructive? [Do inhaled corticosteroids reduce mortality in chronic obstructive pulmonary disease?]
Périodique
Revue Médicale Suisse
Auteur⸱e⸱s
Bridevaux  P. O., Leuenberger  P.
ISSN
1660-9379 (Print)
Statut éditorial
Publié
Date de publication
11/2005
Volume
1
Numéro
41
Pages
2673-4, 2677-9
Notes
English Abstract
Journal Article
Review --- Old month value: Nov 16
Résumé
In Switzerland, high dose of inhaled corticosteroids are frequently prescribed to COPD patients. Observational studies have suggested a reduction in mortality, although several randomised controlled trials did not show such a beneficial effect. Two important exposure biases are highlighted by a careful review of the methodological aspects of these observational studies: the immortal time bias and the failure to perform a time dependent analysis lead to underestimate the risk of death among exposed patients therefore incorrectly suggesting a survival benefit of regular inhaled steroid use. Two recent pharmaco-epidemiological studies, controlling for these exposure biases did not find any reduction in mortality due to inhaled steroids among COPD patients.
Mots-clé
Administration, Inhalation Adrenal Cortex Hormones/*administration & dosage Clinical Trials Humans Pulmonary Disease, Chronic Obstructive/*drug therapy/*mortality
Pubmed
Création de la notice
25/01/2008 9:49
Dernière modification de la notice
20/08/2019 15:23
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