Clinical prediction of deep venous thrombosis using two risk assessment methods in combination with rapid quantitative D-dimer testing
Détails
ID Serval
serval:BIB_B568E54191F9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Clinical prediction of deep venous thrombosis using two risk assessment methods in combination with rapid quantitative D-dimer testing
Périodique
American Journal of Medicine
ISSN
0002-9343 (Print)
Statut éditorial
Publié
Date de publication
02/2002
Volume
112
Numéro
3
Pages
198-203
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb 15
Research Support, Non-U.S. Gov't --- Old month value: Feb 15
Résumé
PURPOSE: The optimal approach to diagnosing deep venous thrombosis is not entirely clear. In this prospective cohort study, we aimed to evaluate the yield of two methods of assessing the pretest probability of deep venous thrombosis-the treating physician's implicit assessment and the Wells score, a validated prediction rule that incorporates signs, symptoms, and the presence or absence of an alternative diagnosis-used in isolation and in combination with D-dimer measurement. SUBJECTS AND METHODS: We studied 278 patients who were referred for suspicion of deep venous thrombosis. All patients were stratified into groups of low, moderate, or high risk of deep venous thrombosis on the basis of the clinical assessment and Wells score, and underwent rapid quantitative D-dimer testing (with a cutoff of 500 microg/mL), ultrasound examination, and follow-up for the occurrence of venous thromboembolism. RESULTS: Eighty-two patients (29%) had a deep venous thrombosis. The accuracy of both methods was good (area under the receiver operating characteristic curve = 0.72), despite only fair agreement at the level of individual patients (weighted kappa = 0.31; 95% confidence interval [CI]: 0.23 to 0.40). The negative predictive value of D-dimer measurement was 96% (95% CI: 91% to 100%). When restricted to patients with low pretest probability, the negative predictive value of D-dimer measurement was 100% (95% CI: 96% to 100%) with the use of the Wells score and 96% (95% CI: 88% to 100%) with the physician's assessment. Our results were unchanged in analyses restricted to patients with proximal deep venous thrombosis or outpatients. CONCLUSION: Clinical assessment to stratify a patient's likelihood of having deep venous thrombosis should be taught to physicians.
Mots-clé
Aged
Female
Fibrin Fibrinogen Degradation Products/*diagnostic use
Humans
Male
Middle Aged
Predictive Value of Tests
Prospective Studies
ROC Curve
Risk Assessment
Venous Thrombosis/*diagnosis/ultrasonography
Pubmed
Web of science
Création de la notice
25/01/2008 14:41
Dernière modification de la notice
20/08/2019 16:23